Recombinant EXOC2 antibody

Catalog No. ABIN7880755

The Rabbit Monoclonal anti-EXOC2 antibody (Clone 31E49) (ABIN7880755) specifically detects EXOC2 in WB. The antibody is reactive with Human, Mouse and Rat samples.

Quick Overview for Recombinant EXOC2 antibody (ABIN7880755)

Target: EXOC2 (Exocyst Complex Component 2 (EXOC2))

Antibody Type: Recombinant Antibody

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Monoclonal

Conjugate: This EXOC2 antibody is un-conjugated

Application: Western Blotting (WB)

Clone: 31E49

Product Details anti-EXOC2 Antibody

Purpose: EXOC2 Antibody / Exocyst complex component 2

Purification: Affinity-chromatography

Immunogen: A synthesized peptide derived from human EXOC2 was used as the immunogen for the EXOC2 antibody.

Isotype: IgG

Application Details

Application Notes: Optimal dilution of the EXOC2 antibody should be determined by the researcher.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Rabbit IgG in phosphate buffered saline, pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol, 0.4-0.5 mg/mL BSA.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store the EXOC2 antibody at -20oC.

Target Details for EXOC2

Target: EXOC2 (Exocyst Complex Component 2 (EXOC2))

Alternative Name: EXOC2

Background: EXOC2 antibody detects exocyst complex component 2, a critical member of the octameric exocyst complex that regulates tethering of secretory vesicles to the plasma membrane. This protein, also known as Sec5, functions in exocytosis and polarized trafficking, ensuring cargo delivery to specific membrane domains. By organizing vesicle docking, EXOC2 plays a fundamental role in processes such as cell migration, epithelial polarity, and neurite outgrowth. Its interactions with Ral GTPases highlight its role in small GTPase-mediated trafficking control.

Research using EXOC2 antibody has connected this protein to cancer and neurological disorders. Overexpression of EXOC2 has been reported in several tumor types, where it may promote invasive behavior by enhancing targeted membrane addition and secretion of proteases. In neurons, altered exocyst function has been linked to impaired synaptic vesicle recycling and neurodevelopmental defects. Investigating EXOC2 therefore provides insight into both normal cellular organization and disease pathology.

Antibodies against EXOC2 have been validated in western blot, immunohistochemistry, and immunoprecipitation. These tools help characterize exocyst assembly, subcellular localization, and interactions with signaling proteins. High-specificity clones are particularly valuable for distinguishing EXOC2 from related exocyst components within large multiprotein complexes.

NSJ Bioreagents supplies this EXOC2 antibody for research applications in membrane trafficking, cancer biology, and neurobiology. Alternate names include exocyst complex component 2 antibody, Sec5 antibody, SEC5L1 antibody, and Sec5p antibody.

UniProt: Q96KP1

Pathways: Peptide Hormone Metabolism, Regulation of Actin Filament Polymerization, Synaptic Vesicle Exocytosis