Growth Hormone Receptor antibody

Catalog No. ABIN7880933

This Rabbit Monoclonal antibody specifically detects Growth Hormone Receptor in WB. It exhibits reactivity toward Human and Mouse.

Quick Overview for Growth Hormone Receptor antibody (ABIN7880933)

Target: Growth Hormone Receptor (GHR)

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Monoclonal

Conjugate: This Growth Hormone Receptor antibody is un-conjugated

Application: Western Blotting (WB)

Clone: 17G57

Product Details anti-Growth Hormone Receptor Antibody

Purpose: GHR Antibody / Growth Hormone Receptor

Purification: Affinity purified

Immunogen: A synthetic peptide specific to human Growth Hormone Receptor / GHR was used as the immunogen for the GHR antibody.

Isotype: IgG

Application Details

Application Notes: Optimal dilution of the GHR antibody should be determined by the researcher.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Antibody in PBS with 0.02 % sodium azide, 50 % glycerol and 0.4-0.5 mg/mL BSA

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store the GHR antibody at -20oC.

Target Details for Growth Hormone Receptor

Target: Growth Hormone Receptor (GHR)

Alternative Name: GHR

Background: The GHR gene encodes a member of the type I cytokine receptor family, which is a transmembrane receptor for growth hormone. Binding of growth hormone to the receptor leads to receptor dimerization and the activation of an intra- and intercellular signal transduction pathway leading to growth. Mutations in this gene have been associated with Laron syndrome, also known as the growth hormone insensitivity syndrome (GHIS), a disorder characterized by short stature. In humans and rabbits, but not rodents, growth hormone binding protein (GHBP) is generated by proteolytic cleavage of the extracellular ligand-binding domain from the mature growth hormone receptor protein. Multiple alternatively spliced transcript variants have been found for this gene. [RefSeq]

UniProt: P10912

Pathways: NF-kappaB Signaling, JAK-STAT Signaling, Response to Growth Hormone Stimulus