HMGB1 antibody

Catalog No. ABIN7881045

The Rabbit Monoclonal anti-HMGB1 antibody is suitable to detect HMGB1 in samples from Human and Rat. It has been validated for WB and IHC (p).

Quick Overview for HMGB1 antibody (ABIN7881045)

Target: HMGB1 (High Mobility Group Box 1 (HMGB1))

Reactivity: Human, Rat

Host: Rabbit

Clonality: Monoclonal

Conjugate: This HMGB1 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Clone: AAC-8

Product Details anti-HMGB1 Antibody

Purpose: HMGB1 Antibody

Purification: Affinity purified

Immunogen: A synthetic peptide specific to human HMGB1 was used as the immunogen for the HMGB1 antibody.

Isotype: IgG

Application Details

Application Notes: Optimal dilution of the HMGB1 antibody should be determined by the researcher.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Antibody in PBS with 0.02 % sodium azide, 50 % glycerol and 0.4-0.5 mg/mL BSA

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store the HMGB1 antibody at -20oC.

Target Details for HMGB1

Target: HMGB1 (High Mobility Group Box 1 (HMGB1))

Alternative Name: HMGB1

Background: High mobility group protein B1 is a multifunctional redox sensitive protein with various roles in different cellular compartments. In the nucleus is one of the major chromatin-associated non-histone proteins and acts as a DNA chaperone involved in replication, transcription, chromatin remodeling, V(D)J recombination, DNA repair and genome stability. [UniProt]

UniProt: P09429

Pathways: p53 Signaling, Regulation of Muscle Cell Differentiation, Skeletal Muscle Fiber Development, Positive Regulation of Endopeptidase Activity, Regulation of Carbohydrate Metabolic Process, Toll-Like Receptors Cascades, Smooth Muscle Cell Migration, Inflammasome