HSD17B2 antibody

Catalog No. ABIN7881141

The Rabbit Polyclonal anti-HSD17B2 antibody is suitable to detect HSD17B2 in samples from Human. It has been validated for WB and FACS.

Quick Overview for HSD17B2 antibody (ABIN7881141)

Target: HSD17B2 (Hydroxysteroid (17-Beta) Dehydrogenase 2 (HSD17B2))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This HSD17B2 antibody is un-conjugated

Application: Western Blotting (WB), Flow Cytometry (FACS)

Product Details anti-HSD17B2 Antibody

Purpose: HSD17B2 Antibody

Sequence: IYDYFAKRHF GQDK

Purification: Affinity purified

Immunogen: Amino acids IYDYFAKRHFGQDK from the human protein were used as the immunogen for the HSD17B2 antibody.

Isotype: IgG

Application Details

Application Notes: Optimal dilution of the HSD17B2 antibody should be determined by the researcher.

Restrictions: For Research Use only

Handling

Format: Lyophilized

Buffer: 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water

Storage: 4 °C,-20 °C

Storage Comment: After reconstitution, the HSD17B2 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

Target Details for HSD17B2

Target: HSD17B2 (Hydroxysteroid (17-Beta) Dehydrogenase 2 (HSD17B2))

Alternative Name: HSD17B2

Background: HSD17B2 (17-BETA-HYDROXYSTEROID DEHYDROGENASE II), also called 17-BETA-HSD II, is an anzyme which have 387 amino acids with a predicted molecular weight of 42,782 and associate with the membranes of the endoplasmic reticulum. Its Cytogenetic location is 16q23.3. The type 2 enzyme was capable of catalyzing the interconversion of testosterone and androstenedione, as well as estradiol and estrone. HSD17B2 mRNA was detected in 18 of 42 (43 % ) adenomas but not in prolactinomas. In the human endometrium, inactivation of 17-beta-estradiol to estrone is catalyzed by HSD17B2. And HSD17B2 activity distinguishing between disease-free and diseased endometria. HSD17B2 efficiently catalyzes the oxidative metabolism of androgens and estrogens, and it is expressed in a large series of human peripheral tissues. The previous paradigm that HSD17B2 activity in the endometrium is elevated during the secretory phase is confined to diseased endometrium but not to disease-free endometrium.

UniProt: P37059

Pathways: Steroid Hormone Biosynthesis