IL-15 antibody

Catalog No. ABIN7881283

The Mouse Monoclonal anti-IL-15 antibody is suitable to detect IL-15 in samples from Human. It has been validated for IHC (p).

Quick Overview for IL-15 antibody (ABIN7881283)

Target: IL-15 (IL15) (Interleukin 15 (IL15))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This IL-15 antibody is un-conjugated

Application: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Grade: Carrier-free

Clone: IL15-4696

Product Details anti-IL-15 Antibody

Purpose: Interleukin-15 Antibody / IL15 (azide and preservative free)

Purification: Protein A/G affinity

Immunogen: A recombinant fragment of human IL15 was used as the immunogen for the Interleukin-15 antibody.

Isotype: IgG2, kappa

Application Details

Application Notes: Optimal dilution of the Interleukin-15 antibody should be determined by the researcher.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: 1 mg/mL in 1X PBS, BSA free, sodium azide free

Preservative: Azide free

Storage: -20 °C

Storage Comment: Aliquot the Interleukin-15 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

Target Details for IL-15

Target: IL-15 (IL15) (Interleukin 15 (IL15))

Alternative Name: Interleukin-15

Background: Interleukin-15 (IL-15), also designated IL-T, is a cloned cytokine which shares several biological activities but no sequence homology with IL-2. Human, mouse and simian IL-15 cDNA clones have been isolated and characterized. All 3 species encode a 162 amino acid residue precursor protein containing a 48 amino acid leader that is cleaved to generate the mature form of IL-15. IL-15 stimulates the proliferation of T cells and NK cells, while enhancing B cell expansion and antibody production. Unlike IL-2, IL-15 is not produced by lymphocytes, but appears to be produced by macrophages, epithelial lines, muscle and placenta. IL-15 has also been shown to be a chemoattractant for human blood T lymphocytes and to be able to induce lymphokine-activated killer (LAK) activity in NK cells as well as to be able to induce the generation of cytolytic effector cells. Studies have shown that IL-15 is the only other cytokine that shares the beta signaling subunit of the IL-2R. Evidence also suggests that like IL-2, IL-4 and IL-7, IL-15 utilizes the common IL-2Rgamma subunit.

UniProt: P40933

Pathways: JAK-STAT Signaling, Glycosaminoglycan Metabolic Process