IL-3 antibody

Catalog No. ABIN7881308

The Mouse Monoclonal anti-IL-3 antibody (Clone IL3-4003) (ABIN7881308) specifically detects IL-3 in IHC (p). The antibody is reactive with Human samples.

Quick Overview for IL-3 antibody (ABIN7881308)

Target: IL-3 (Interleukin 3 (IL-3))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This IL-3 antibody is un-conjugated

Application: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Clone: IL3-4003

Product Details anti-IL-3 Antibody

Purpose: IL-3 Antibody / Interleukin 3

Purification: Protein A/G affinity

Immunogen: A recombinant fragment of human Interleukin 3 protein was used as the immunogen for the IL-3 antibody.

Isotype: IgG1, kappa

Application Details

Application Notes: Optimal dilution of the IL-3 antibody should be determined by the researcher.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.2 mg/mL

Buffer: 0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced), 0.05 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Aliquot the IL-3 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

Target Details for IL-3

Target: IL-3 (Interleukin 3 (IL-3))

Alternative Name: IL-3

Background: Interleukin-3, or IL-3, is a pleiotropic cytokine that is primarily secreted by activated T lymphocytes and stimulates the proliferation and differentiation of hematopoietic cells. IL-3 not only supports growth of both pluripotent stem cells and the more differentiated committed progenitors, but it also stimulates the functional activity of some fully differentiated cells. IL-3 has also been shown to protect mast cells from undergoing apoptosis. IL-3 exerts its biological effects through a receptor which consists of a ligand-specific Alpha subunit and a signal transducing beta subunit common to the IL-3/IL-5/GM-CSF receptors. The carboxy terminus of the beta subunit has been shown to be necessary for activation of the MAP kinase signaling pathway. Although the IL-3 receptor has no intrinsic kinase activity, stimulation with IL-3 leads to tyrosine phosphorylation of the JAK/Tyk 2 family member, JAK2, which in turn activates and causes nuclear translocation of Stat5a and Stat5b.

UniProt: P08700

Pathways: JAK-STAT Signaling, Regulation of Carbohydrate Metabolic Process, Autophagy