Recombinant Cytokeratin 13 antibody

Catalog No. ABIN7881353

The Rabbit Monoclonal anti-Cytokeratin 13 antibody (Clone KRT13-8577R) (ABIN7881353) specifically detects Cytokeratin 13 in IHC (p). The antibody is reactive with Human samples.

Quick Overview for Recombinant Cytokeratin 13 antibody (ABIN7881353)

Target: Cytokeratin 13 (KRT13) (Keratin 13 (KRT13))

Antibody Type: Recombinant Antibody

Reactivity: Human

Host: Rabbit

Clonality: Monoclonal

Conjugate: This Cytokeratin 13 antibody is un-conjugated

Application: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Grade: Carrier-free

Clone: KRT13-8577R

Product Details anti-Cytokeratin 13 Antibody

Purpose: CK13 Antibody / Cytokeratin 13 (azide and preservative free)

Purification: Protein A affinity

Immunogen: Esophageal keratins of rabbit origin were used as the immunogen for the CK13 antibody.

Isotype: IgG, kappa

Application Details

Application Notes: Optimal dilution of the CK13 antibody should be determined by the researcher.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: 1 mg/mL in 1X PBS, BSA free, sodium azide free

Preservative: Azide free

Storage: -20 °C

Storage Comment: Aliquot the CK13 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

Target Details for Cytokeratin 13

Target: Cytokeratin 13 (KRT13) (Keratin 13 (KRT13))

Alternative Name: CK13

Background: Cytokeratins comprise a diverse group of intermediate filament proteins (IFPs) that are expressed as pairs in both keratinized and non-keratinized epithelial tissue. Cytokeratins play a critical role in differentiation and tissue specialization and function to maintain the overall structural integrity of epithelial cells. Cytokeratins have been found to be useful markers of tissue differentiation, which is directly applicable to the characterization of malignant tumors. Cytokeratins 10 and 13 are present in the cytoskeletal region of a subset of squamous cell carcinomas. Cytokeratin 13 belongs to the intermediate filament family and is a heterotetramer of two type I acidic and two type II basic keratins. It is generally associated with Cytokeratin 4. Defects in the KRT13 gene are a cause of white sponge nevus of cannon (WSN), a rare autosomal dominant disorder which predominantly affects noncornified stratified squamous epithelia and is characterized by the presence of soft, white and spongy plaques in the oral mucosa.

UniProt: P13646