Keratin 7/17 antibody

Catalog No. ABIN7881418

The Mouse Monoclonal anti-Keratin 7/17 antibody is suitable to detect Keratin 7/17 in samples from Human. It has been validated for WB, IHC (p) and IF.

Quick Overview for Keratin 7/17 antibody (ABIN7881418)

Target: Keratin 7/17 (KRT7/17)

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This Keratin 7/17 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunofluorescence (IF)

Grade: Carrier-free

Clone: C-46

Product Details anti-Keratin 7/17 Antibody

Purpose: Cytokeratin 7/17 Antibody (azide and preservative free)

Purification: Protein G affinity chromatography

Immunogen: A cytoskeletal preparation from human HeLa cells was used as the immunogen for this Cytokeratin 7/17 antibody.

Isotype: IgG1, kappa

Application Details

Application Notes: Optimal dilution of the Cytokeratin 7/17 antibody should be determined by the researcher.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: 1 mg/mL in 1X PBS, BSA free, sodium azide free

Preservative: Azide free

Storage: 4 °C,-20 °C

Storage Comment: Store the Cytokeratin 7/17 antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).

Target Details for Keratin 7/17

Target: Keratin 7/17 (KRT7/17)

Alternative Name: Cytokeratin 7/17

Background: It recognizes intermediate filament proteins (IFP's) of 55 kDa and 46 kDa, which are identified as Cytokeratin 7 and Cytokeratin 17 respectively. On formalin-fixed, paraffin embedded sections, C-46 reacts with Keratin 7 only. Cytokeratins comprise a diverse group of intermediate filament proteins (IFPs) that are expressed as pairs in both keratinized and non-keratinized epithelial tissue. Cytokeratins play a critical role in differentiation and tissue specialization and function to maintain the overall structural integrity of epithelial cells. Cytokeratins have been found to be useful markers of tissue differentiation, which is directly applicable to the characterization of malignant tumors. Cytokeratin 7 is a basic cytokeratin, which is found in most glandular and transitional epithelia but not in the stratified squamous epithelia. Cytokeratin 7 is expressed in the epithelial cells of ovary, lung, and breast but not of colon, prostate, or gastrointestinal tract. Cytokeratin 17 is expressed in epithelial cells of various origins, such as bronchial epithelial cells and skin appendages. Cytokeratin 17 antibody marks basal cell differentiation.

UniProt: P08729