MFN2 antibody

Catalog No. ABIN7881650

The Rabbit Monoclonal anti-MFN2 antibody (Clone AOCA-13) (ABIN7881650) specifically detects MFN2 in WB. The antibody is reactive with Human and Mouse samples.

Quick Overview for MFN2 antibody (ABIN7881650)

Target: MFN2 (Mitofusin 2 (MFN2))

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Monoclonal

Conjugate: This MFN2 antibody is un-conjugated

Application: Western Blotting (WB)

Clone: AOCA-13

Product Details anti-MFN2 Antibody

Purpose: Mitofusin 2 Antibody / MFN2

Purification: Affinity purified

Immunogen: A synthetic peptide specific to human Mitofusin 2 / MFN2 was used as the immunogen for the Mitofusin 2 antibody.

Isotype: IgG

Application Details

Application Notes: Optimal dilution of the Mitofusin 2 antibody should be determined by the researcher.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Antibody in PBS with 0.02 % sodium azide, 50 % glycerol and 0.4-0.5 mg/mL BSA

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store the Mitofusin 2 antibody at -20oC.

Target Details for MFN2

Target: MFN2 (Mitofusin 2 (MFN2))

Alternative Name: Mitofusin 2

Background: Mitofusin 2 is a mitochondrial outer membrane GTPase that mediates mitochondrial clustering and fusion. Mitochondria are highly dynamic organelles, and their morphology is determined by the equilibrium between mitochondrial fusion and fission events. Overexpression induces the formation of mitochondrial networks. Membrane clustering requires GTPase activity and may involve a major rearrangement of the coiled coil domains (Probable). Plays a central role in mitochondrial metabolism and may be associated with obesity and/or apoptosis processes. Plays an important role in the regulation of vascular smooth muscle cell proliferation. Involved in the clearance of damaged mitochondria via selective autophagy (mitophagy). Is required for PRKN recruitment to dysfunctional mitochondria. [UniProt]

UniProt: O95140

Pathways: Skeletal Muscle Fiber Development