PHPT1 antibody

Catalog No. ABIN7881936

This Mouse Monoclonal antibody specifically detects PHPT1 in IHC (p). It exhibits reactivity toward Human.

Quick Overview for PHPT1 antibody (ABIN7881936)

Target: PHPT1 (phosphohistidine Phosphatase 1 (PHPT1))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This PHPT1 antibody is un-conjugated

Application: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Clone: PHPT1-12054

Product Details anti-PHPT1 Antibody

Purpose: Phosphohistidine phosphatase 1 Antibody / PHPT1

Purification: Protein A/G affinity

Immunogen: A recombinant human 14 kDa phosphohistidine phosphatase protein was used as the immunogen for the Phosphohistidine phosphatase 1 antibody.

Isotype: IgG

Application Details

Application Notes: Optimal dilution of the Phosphohistidine phosphatase 1 antibody should be determined by the researcher.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.2 mg/mL

Buffer: 0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced), 0.05 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Aliquot the Phosphohistidine phosphatase 1 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

Target Details for PHPT1

Target: PHPT1 (phosphohistidine Phosphatase 1 (PHPT1))

Alternative Name: Phosphohistidine phosphatase 1

Background: PHPT1 (phosphohistidine phosphatase 1), also known as 14 kDa phosphohistidine phosphatase, is a 125 amino acid enzyme belonging to the Janus protein family. Existing as a monomer in the cytoplasm, PHPT1 is an EDTAinsensitive phosphohistidine phosphatase. First identified in human adrenal gland, PHPT1 is highly expressed in skeletal muscle and heart, with lower expression in liver, pancreas and kidney. Overexpression of PHPT1 leads to specific phosphohistidine phosphatase activity towards phosphopeptide I, with no activity detected towards phosphotyrosine, phosphothreonine and phosphoserine peptides. PHPT1 is highly conserved among species, suggesting that it serves an essential functional role.

UniProt: Q9NRX4

Pathways: Positive Regulation of Peptide Hormone Secretion