Recombinant PDGFB antibody

Catalog No. ABIN7881962

The Rabbit Monoclonal anti-PDGFB antibody (Clone 31P34) (ABIN7881962) specifically detects PDGFB in WB. The antibody is reactive with Human, Rat and Mouse samples.

Quick Overview for Recombinant PDGFB antibody (ABIN7881962)

Target: PDGFB (Platelet Derived Growth Factor Subunit B (PDGFB))

Antibody Type: Recombinant Antibody

Reactivity: Human, Rat, Mouse

Host: Rabbit

Clonality: Monoclonal

Conjugate: This PDGFB antibody is un-conjugated

Application: Western Blotting (WB)

Clone: 31P34

Product Details anti-PDGFB Antibody

Purpose: PDGFB Antibody / Platelet derived growth factor subunit B

Purification: Affinity chromatography

Immunogen: A synthesized peptide derived from human PDGF B was used as the immunogen for the PDGFB antibody.

Isotype: IgG

Application Details

Application Notes: Optimal dilution of the PDGFB antibody should be determined by the researcher.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Rabbit IgG in phosphate buffered saline, pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol, 0.4-0.5 mg/mL BSA

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store the PDGFB antibody at -20oC.

Target Details for PDGFB

Target: PDGFB (Platelet Derived Growth Factor Subunit B (PDGFB))

Alternative Name: PDGFB

Background: PDGFB antibody detects Platelet derived growth factor subunit B, encoded by the PDGFB gene. Platelet derived growth factor subunit B is a growth factor that dimerizes to form homodimers or heterodimers with the PDGFA subunit, creating PDGF-BB or PDGF-AB ligands. These ligands bind to platelet derived growth factor receptors, initiating signaling cascades that control proliferation, survival, and migration of mesenchymal cells. PDGFB antibody provides researchers with a specific reagent to study angiogenesis, wound healing, and cancer biology.

Platelet derived growth factor subunit B is secreted as part of a larger precursor protein that undergoes proteolytic processing to yield the mature growth factor. Research using PDGFB antibody has demonstrated that PDGF-BB is a potent mitogen for fibroblasts, vascular smooth muscle cells, and pericytes. Its signaling regulates blood vessel development and maintenance, making it essential for embryonic angiogenesis and adult vascular remodeling. Knockout models lacking PDGFB develop severe vascular abnormalities, underscoring its importance in development.

Aberrant expression of Platelet derived growth factor subunit B has been linked to a wide range of diseases. Studies with PDGFB antibody have shown that overexpression promotes tumor growth and angiogenesis by stimulating stromal proliferation and vascular recruitment. In fibrotic disease, excess PDGFB drives fibroblast activation and extracellular matrix deposition. Conversely, deficiency in PDGFB signaling results in defective pericyte recruitment and fragile vasculature. These findings demonstrate its critical role in tissue integrity and pathology.

PDGFB also contributes to neurobiology. Research using PDGFB antibody has revealed that the protein supports neural progenitor proliferation and protects neurons from injury through trophic signaling. Dysregulation has been associated with neurodegenerative conditions and gliomas. Because of its diverse functions across tissues, Platelet derived growth factor subunit B remains an important therapeutic target.

PDGFB antibody is widely applied in western blotting, immunohistochemistry, and ELISA. Western blotting detects mature and precursor forms, immunohistochemistry highlights expression in vasculature and tumors, and ELISA quantifies secreted PDGFB in biological fluids. These applications make PDGFB antibody valuable in both basic and translational research.

By supplying validated PDGFB antibody reagents, NSJ Bioreagents supports studies into growth factor biology, angiogenesis, and cancer. Detection of Platelet derived growth factor subunit B allows researchers to examine how growth factor signaling regulates development, disease, and repair.

UniProt: P01127

Pathways: RTK Signaling, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Regulation of Carbohydrate Metabolic Process, Smooth Muscle Cell Migration, Platelet-derived growth Factor Receptor Signaling