Recombinant PCBP2 antibody

Catalog No. ABIN7881993

This Rabbit Monoclonal antibody specifically detects PCBP2 in WB, IF, ICC and IP. It exhibits reactivity toward Human, Mouse and Rat.

Quick Overview for Recombinant PCBP2 antibody (ABIN7881993)

Target: PCBP2 (Poly(rC) Binding Protein 2 (PCBP2))

Antibody Type: Recombinant Antibody

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Monoclonal

Conjugate: This PCBP2 antibody is un-conjugated

Application: Western Blotting (WB), Immunofluorescence (IF), Immunocytochemistry (ICC), Immunoprecipitation (IP)

Clone: 30P20

Product Details anti-PCBP2 Antibody

Purpose: PCBP2 Antibody / Poly(rC)-binding protein 2

Purification: Affinity-chromatography

Immunogen: A synthesized peptide derived from human PCBP2 was used as the immunogen for the PCBP2 antibody.

Isotype: IgG

Application Details

Application Notes: Optimal dilution of the PCBP2 antibody should be determined by the researcher.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Rabbit IgG in phosphate buffered saline, pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol, 0.4-0.5 mg/mL BSA

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store the PCBP2 antibody at -20oC.

Target Details for PCBP2

Target: PCBP2 (Poly(rC) Binding Protein 2 (PCBP2))

Alternative Name: PCBP2

Background: PCBP2 antibody detects poly(rC)-binding protein 2, an RNA-binding protein that regulates mRNA stability, translation, and alternative splicing. PCBP2 belongs to the heterogeneous nuclear ribonucleoprotein K-homology domain family and binds poly(C)-rich RNA sequences, influencing post-transcriptional control of numerous transcripts. PCBP2 is widely expressed and has essential functions in iron metabolism, viral replication, and gene expression regulation.

Research using PCBP2 antibody has revealed the protein's multifunctional nature. In iron homeostasis, PCBP2 acts as a cytosolic iron chaperone, delivering iron to ferritin for storage and supporting enzymatic cofactors. Its role in viral biology is equally significant: PCBP2 has been shown to bind viral RNA, regulating replication of poliovirus, hepatitis C virus, and enteroviruses. In addition, PCBP2 can function as a negative regulator of antiviral signaling, making it an attractive target in infection research.

In cancer, PCBP2 expression is frequently dysregulated. Overexpression can promote tumorigenesis by stabilizing oncogenic transcripts and influencing signaling pathways. Conversely, loss of PCBP2 disrupts iron metabolism and RNA processing, contributing to genomic instability. Its widespread regulatory functions make it relevant for studies across oncology, virology, and metabolism.

Antibodies against PCBP2 are validated for western blot, immunoprecipitation, immunofluorescence, and immunohistochemistry. These tools allow researchers to examine PCBP2's role in RNA binding, protein interactions, and cellular localization. Clone-based antibodies ensure reliable specificity when distinguishing PCBP2 from other PCBP family members.

NSJ Bioreagents offers this PCBP2 antibody for research in RNA biology, viral replication, and cancer.

UniProt: Q15366