PNP antibody

Catalog No. ABIN7882108

The Mouse Monoclonal anti-PNP antibody is suitable to detect PNP in samples from Human and Rat. It has been validated for WB.

Quick Overview for PNP antibody (ABIN7882108)

Target: PNP (Purine Nucleoside Phosphorylase (PNP))

Reactivity: Human, Rat

Host: Mouse

Clonality: Monoclonal

Conjugate: This PNP antibody is un-conjugated

Application: Western Blotting (WB)

Clone: 2H10

Product Details anti-PNP Antibody

Purpose: Purine nucleoside phosphorylase Antibody / PNP / Inosine phosphorylase

Sequence: AMSDAYDRTM RQRALSTWKQ MGEQRELQE

Purification: Antigen affinity purified

Immunogen: Amino acids AMSDAYDRTMRQRALSTWKQMGEQRELQE were used as the immunogen for the Purine nucleoside phosphorylase antibody.

Isotype: IgG2b

Application Details

Application Notes: Optimal dilution of the Purine nucleoside phosphorylase antibody should be determined by the researcher.

Restrictions: For Research Use only

Handling

Format: Lyophilized

Buffer: 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water

Storage: 4 °C,-20 °C

Storage Comment: After reconstitution, the Purine nucleoside phosphorylase antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

Target Details for PNP

Target: PNP (Purine Nucleoside Phosphorylase (PNP))

Alternative Name: Purine nucleoside phosphorylase

Background: The PNP gene encodes purine nucleoside phosphorylase, an enzyme that catalyzes the reversible phosphorolysis of the purine nucleosides and deoxynucleosides inosine, guanosine, deoxyinosine, and deoxyguanosine. It is presented results from gene dosage studies consistent with assignment of the PNP locus to band 14q13. PNP is expressed in most tissues, with markedly greater expression in lymphoid tissues. Genetic deficiencies of PNP result in severely compromised T?lymphocyte function and neurologic dysfunction.

UniProt: P00491

Pathways: Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Ribonucleoside Biosynthetic Process, Positive Regulation of Response to DNA Damage Stimulus