PDHA1 antibody

Catalog No. ABIN7882116

This Rabbit Monoclonal antibody specifically detects PDHA1 in WB. It exhibits reactivity toward Human.

Quick Overview for PDHA1 antibody (ABIN7882116)

Target: PDHA1 (Pyruvate Dehydrogenase (Lipoamide) alpha 1 (PDHA1))

Reactivity: Human

Host: Rabbit

Clonality: Monoclonal

Conjugate: This PDHA1 antibody is un-conjugated

Application: Western Blotting (WB)

Clone: AODI-16

Product Details anti-PDHA1 Antibody

Purpose: PDHA1 Antibody / Pyruvate Dehydrogenase E1 Alpha

Purification: Affinity purified

Immunogen: A synthetic peptide specific to human Pdh E1 Alpha / PDHA1 was used as the immunogen for the PDHA1 antibody.

Isotype: IgG

Application Details

Application Notes: Optimal dilution of the PDHA1 antibody should be determined by the researcher.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Antibody in PBS with 0.02 % sodium azide, 50 % glycerol and 0.4-0.5 mg/mL BSA

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store the PDHA1 antibody at -20oC.

Target Details for PDHA1

Target: PDHA1 (Pyruvate Dehydrogenase (Lipoamide) alpha 1 (PDHA1))

Alternative Name: PDHA1

Background: The pyruvate dehydrogenase (PDH) complex is a nuclear-encoded mitochondrial multienzyme complex that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2), and provides the primary link between glycolysis and the tricarboxylic acid (TCA) cycle. The PDH complex is composed of multiple copies of three enzymatic components: pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydrogenase (E3). The E1 enzyme is a heterotetramer of two alpha and two beta subunits. This gene encodes the E1 alpha 1 subunit containing the E1 active site, and plays a key role in the function of the PDH complex. Mutations in this gene are associated with pyruvate dehydrogenase E1-alpha deficiency and X-linked Leigh syndrome. [RefSeq]

UniProt: P08559

Pathways: Warburg Effect