Recombinant RAPGEF4 antibody

Catalog No. ABIN7882136

The Rabbit Monoclonal anti-RAPGEF4 antibody (Clone 22R17) (ABIN7882136) specifically detects RAPGEF4 in WB and IHC (p). The antibody is reactive with Human, Mouse and Rat samples.

Quick Overview for Recombinant RAPGEF4 antibody (ABIN7882136)

Target: RAPGEF4 (Rap Guanine Nucleotide Exchange Factor (GEF) 4 (RAPGEF4))

Antibody Type: Recombinant Antibody

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Monoclonal

Conjugate: This RAPGEF4 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Clone: 22R17

Product Details anti-RAPGEF4 Antibody

Purpose: RAPGEF4 Antibody / EPAC 2

Purification: Affinity chromatography

Immunogen: A peptide sequence specific to Rap guanine nucleotide exchange factor 4 protein was used as the immunogen for the RAPGEF4 antibody.

Isotype: IgG

Application Details

Application Notes: Optimal dilution of the RAPGEF4 antibody should be determined by the researcher.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Antibody in PBS with 0.02 % sodium azide, 50 % glycerol and 0.4-0.5 mg/mL BSA

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: After reconstitution, the RAPGEF4 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

Target Details for RAPGEF4

Target: RAPGEF4 (Rap Guanine Nucleotide Exchange Factor (GEF) 4 (RAPGEF4))

Alternative Name: RAPGEF4

Background: Rap guanine nucleotide exchange factor 4 (RAPGEF4), also known as EPAC 2 (Exchange protein directly activated by cAMP 2), is a cAMP-regulated guanine nucleotide exchange factor that activates Rap1 and Rap2 small GTPases. Unlike protein kinase A, RAPGEF4 mediates cAMP signaling through a PKA-independent pathway, influencing processes such as cell adhesion, insulin secretion, and synaptic plasticity.

RAPGEF4 is expressed predominantly in the brain and endocrine tissues, where it contributes to learning and memory, hormone release, and neuronal signaling. Altered RAPGEF4 function has been implicated in metabolic disorders, neuropsychiatric conditions, and cancer, making it a significant target for biomedical research.

Using a high-quality RAPGEF4 antibody allows for sensitive detection in applications such as western blot, immunohistochemistry, and immunofluorescence. A RAPGEF4 antibody from NSJ Bioreagents ensures reliable and reproducible performance for studies in cAMP signaling, neuronal function, and endocrine regulation. Selecting the right RAPGEF4 antibody is essential for achieving accurate and consistent experimental results.

UniProt: Q8WZA2

Pathways: Hormone Transport, Smooth Muscle Cell Migration