Reticulon 4 antibody

Catalog No. ABIN7882153

The Rabbit Polyclonal anti-Reticulon 4 antibody is suitable to detect Reticulon 4 in samples from Human and Mouse. It has been validated for WB, FACS, IHC (p) and IF.

Quick Overview for Reticulon 4 antibody (ABIN7882153)

Target: Reticulon 4 (RTN4)

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Reticulon 4 antibody is un-conjugated

Application: Western Blotting (WB), Flow Cytometry (FACS), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunofluorescence (IF)

Product Details anti-Reticulon 4 Antibody

Purpose: Nogo A Antibody / RTN4 / Reticulon 4

Sequence: VSNNILHNQQ ELPTALTKLV

Purification: Affinity purified

Immunogen: Amino acids VSNNILHNQQELPTALTKLV from the human protein were used as the immunogen for the Nogo A antibody.

Isotype: IgG

Application Details

Application Notes: Optimal dilution of the Nogo A antibody should be determined by the researcher.

Restrictions: For Research Use only

Handling

Format: Lyophilized

Buffer: 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water

Storage: 4 °C,-20 °C

Storage Comment: After reconstitution, the Nogo A antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

Target Details for Reticulon 4

Target: Reticulon 4 (RTN4)

Alternative Name: Nogo A

Background: Human neurite outgrowth inhibitor (NOGO) cDNAs encodes 3 splice variants: NOGOA, NOGOB and NOGOC. The longest cDNA, designated NOGOA, has an open reading frame of 1192 amino acids. It is a potent inhibitor of neurite growth and an IN-1 antigen produced by oligodendrocytes, and may allow the generation of new reagents to enhance CNS regeneration and plasticity. Nogo-A, a member of the Reticulon family, is expressed by oligodendrocytes and associates primarily with the endoplasmic reticulum. The acidic amino terminus of Nogo-A is detected at the cytosolic face of cellular membranes and may contribute to inhibition of axon regeneration at sites of oligodendrocyte injury. A multivalent form of the N terminus of Nogo-A affects the morphology of both neurons and other cell types.

UniProt: Q9NQC3

Pathways: Neurotrophin Signaling Pathway, Regulation of Cell Size, SARS-CoV-2 Protein Interactome