SKIP antibody

Catalog No. ABIN7882278

This Mouse Monoclonal antibody specifically detects SKIP in FACS. It exhibits reactivity toward Human.

Quick Overview for SKIP antibody (ABIN7882278)

Target: SKIP

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: Un-conjugated

Application: Flow Cytometry (FACS)

Clone: PCRP-SNW1-2A1

Product Details

Purpose: SKIP Antibody / SNW1 / NCoA-62

Purification: Protein A/G affinity

Immunogen: A recombinant fragment of human protein was used as the immunogen for the SKIP antibody.

Isotype: IgG2a

Application Details

Application Notes: Optimal dilution of the SKIP antibody should be determined by the researcher.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.2 mg/mL

Buffer: 0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced), 0.05 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Aliquot the SKIP antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

Target Details

Target: SKIP

Background: Nuclear receptor coactivator NCOA62/SNW1 (also called Nuclear Protein SkiP, SKIIP, Ski-interacting protein) is a member of the SNW gene family, encodes a coactivator that enhances transcription from some Pol II promoters. This coactivator can bind to the ligand-binding domain of the vitamin D receptor and to retinoid receptors to enhance vitamin D-, retinoic acid-, estrogen-, and glucocorticoid-mediated gene expression. It can also interact with poly(A)-binding protein 2 to directly control the expression of muscle-specific genes at the transcriptional level. Finally, the protein may be involved in oncogenesis since it interacts with a region of SKI oncoproteins that is required for transforming activity.

UniProt: Q13573