Recombinant SNX5 antibody

Catalog No. ABIN7882339

The Rabbit Monoclonal anti-SNX5 antibody is suitable to detect SNX5 in samples from Human, Mouse and Rat. It has been validated for WB, IHC, IF and ICC.

Quick Overview for Recombinant SNX5 antibody (ABIN7882339)

Target: SNX5 (Sorting Nexin 5 (SNX5))

Antibody Type: Recombinant Antibody

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Monoclonal

Conjugate: This SNX5 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF), Immunocytochemistry (ICC)

Clone: 30S11

Product Details anti-SNX5 Antibody

Purpose: SNX5 Antibody / Sorting nexin 5

Purification: Affinity-chromatography

Immunogen: A synthesized peptide derived from human SNX5 was used as the immunogen for the SNX5 antibody.

Isotype: IgG

Application Details

Application Notes: Optimal dilution of the SNX5 antibody should be determined by the researcher.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Rabbit IgG in phosphate buffered saline, pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol, 0.4-0.5 mg/mL BSA

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store the SNX5 antibody at -20oC.

Target Details for SNX5

Target: SNX5 (Sorting Nexin 5 (SNX5))

Alternative Name: SNX5

Background: SNX5 antibody detects sorting nexin 5, a member of the sorting nexin family that regulates endosomal trafficking and membrane remodeling. SNX5 contains a phox homology (PX) domain, which binds phosphoinositides on endosomal membranes, and a BAR domain, which promotes membrane curvature and tubulation. Together, these domains allow SNX5 to coordinate cargo retrieval from endosomes and direct proteins to specific intracellular destinations.

Research using SNX5 antibody has shown that SNX5 participates in the retromer complex, where it cooperates with other sorting nexins such as SNX1 and SNX2 to mediate retrograde transport of receptors and enzymes. Disruption of SNX5 function impairs recycling of critical cargo such as cation-independent mannose-6-phosphate receptors, affecting lysosomal enzyme trafficking. These defects can contribute to lysosomal storage disorders and cellular stress responses.

SNX5 has also been linked to viral infection and cancer biology. Certain viruses exploit SNX5-mediated endosomal pathways to promote entry and replication, while altered expression of SNX5 in cancer may influence cell signaling, proliferation, and migration. Its role in trafficking growth factor receptors underscores its significance in tumor biology. In immune cells, SNX5 contributes to antigen presentation by regulating transport of major histocompatibility complex molecules.

Antibodies against SNX5 are validated for western blot, immunohistochemistry, and immunofluorescence. These tools enable analysis of protein expression, intracellular localization, and retromer function. Clone-based antibodies ensure specificity, distinguishing SNX5 from other sorting nexins with overlapping roles.

NSJ Bioreagents provides this SNX5 antibody to support studies in endosomal trafficking, retromer biology, and disease pathways.

UniProt: Q9Y5X3