SPOP-B antibody

Catalog No. ABIN7882341

This Rabbit Polyclonal antibody specifically detects SPOP-B in WB. It exhibits reactivity toward Human.

Quick Overview for SPOP-B antibody (ABIN7882341)

Target: SPOP-B (Speckle-Type POZ Protein (SPOP-B))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This SPOP-B antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-SPOP-B Antibody

Purpose: SPOP Antibody / Speckle-type POZ protein

Sequence: LHSADQLKTQ AVDFINYHAS DVLE

Purification: Antigen affinity purified

Immunogen: Amino acids LHSADQLKTQAVDFINYHASDVLE from the human protein were used as the immunogen for the SPOP antibody.

Isotype: IgG

Application Details

Application Notes: Optimal dilution of the SPOP antibody should be determined by the researcher.

Restrictions: For Research Use only

Handling

Format: Lyophilized

Buffer: 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water

Storage: 4 °C,-20 °C

Storage Comment: After reconstitution, the SPOP antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

Target Details for SPOP-B

Target: SPOP-B (Speckle-Type POZ Protein (SPOP-B))

Alternative Name: SPOP

Background: Speckle-type POZ protein is a protein that in humans is encoded by the SPOP gene. This gene encodes a protein that may modulate the transcriptional repression activities of death-associated protein 6 (DAXX), which interacts with histone deacetylase, core histones, and other histone-associated proteins. In mouse, the encoded protein binds to the putative leucine zipper domain of macroH2A1.2, a variant H2A histone that is enriched on inactivated X chromosomes. The BTB/POZ domain of this protein has been shown in other proteins to mediate transcriptional repression and to interact with components of histone deacetylase co-repressor complexes. Alternative splicing of this gene results in multiple transcript variants encoding the same protein.

UniProt: O43791