Spectrin beta Chain, Erythrocyte (SPTB) antibody

Catalog No. ABIN7882347

This Mouse Monoclonal antibody specifically detects Spectrin beta Chain, Erythrocyte in WB, IF and IHC (p). It exhibits reactivity toward Human.

Quick Overview for Spectrin beta Chain, Erythrocyte (SPTB) antibody (ABIN7882347)

Target: Spectrin beta Chain, Erythrocyte (SPTB)

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: Un-conjugated

Application: Western Blotting (WB), Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Grade: Carrier-free

Clone: RG-26

Product Details

Purpose: SPTB Antibody / Spectrin beta (azide and preservative free)

Purification: Protein G affinity chromatography

Immunogen: Red cell membranes were used as the immunogen for this Spectrin beta antibody.

Isotype: IgG2a, kappa

Application Details

Application Notes: Optimal dilution of the SPTB antibody should be determined by the researcher.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: 1 mg/mL in 1X PBS, BSA free, sodium azide free

Preservative: Azide free

Storage: 4 °C,-20 °C

Storage Comment: Store the SPTB antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).

Target Details

Target: Spectrin beta Chain, Erythrocyte (SPTB)

Alternative Name: SPTB

Background: Spectrin is a cytoskeletal protein that lines the intracellular side of the plasma membrane of many cell types in pentagonal or hexagonal arrangements, forming a scaffolding and playing an important role in maintenance of plasma membrane integrity and cytoskeletal structure. In certain types of brain injury such as diffuse axonal injury, spectrin is irreversibly cleaved by the proteolytic enzyme calpain, destroying the cytosketelon. Spectrin cleavage causes the membrane to form blebs and ultimately to be degraded, usually leading to cell death.

UniProt: P11277

Pathways: Regulation of Actin Filament Polymerization