Recombinant SOCS7 antibody

Catalog No. ABIN7882392

This Rabbit Monoclonal antibody specifically detects SOCS7 in WB and IHC. It exhibits reactivity toward Human.

Quick Overview for Recombinant SOCS7 antibody (ABIN7882392)

Target: SOCS7 (Suppressor of Cytokine Signaling 7 (SOCS7))

Antibody Type: Recombinant Antibody

Reactivity: Human

Host: Rabbit

Clonality: Monoclonal

Conjugate: This SOCS7 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Clone: 30S97

Product Details anti-SOCS7 Antibody

Purpose: SOCS7 Antibody / Suppressor of cytokine signaling 7

Purification: Affinity-chromatography

Immunogen: A synthesized peptide derived from human SOCS7 was used as the immunogen for the SOCS7 antibody.

Isotype: IgG

Application Details

Application Notes: Optimal dilution of the SOCS7 antibody should be determined by the researcher.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Rabbit IgG in phosphate buffered saline, pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol, 0.4-0.5 mg/mL BSA

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store the SOCS7 antibody at -20oC.

Target Details for SOCS7

Target: SOCS7 (Suppressor of Cytokine Signaling 7 (SOCS7))

Alternative Name: SOCS7

Background: SOCS7 antibody detects Suppressor of cytokine signaling 7, encoded by the SOCS7 gene. Suppressor of cytokine signaling 7 belongs to the SOCS family of proteins that negatively regulate cytokine and growth factor signaling through the JAK-STAT pathway. By acting as feedback inhibitors, SOCS proteins help maintain immune balance and prevent excessive signaling. SOCS7 antibody provides researchers with a key reagent to study signal regulation, immune homeostasis, and disease.

Suppressor of cytokine signaling 7 contains a central SH2 domain and a C terminal SOCS box, which targets signaling complexes for ubiquitination and proteasomal degradation. Research using SOCS7 antibody has shown that it regulates not only STAT pathways but also insulin receptor and growth factor receptor signaling. This broadens its role beyond immune regulation into metabolism and growth control. Because it functions as a scaffold that recruits ubiquitin ligases, SOCS7 coordinates protein turnover of key signaling mediators.

In addition to its signaling roles, SOCS7 has nuclear functions. Studies with SOCS7 antibody have demonstrated that the protein translocates to the nucleus in response to DNA damage and stress, where it interacts with signaling and structural proteins to regulate cell cycle checkpoints. This nuclear activity links SOCS7 to genome stability and cellular stress responses, making it more than a classic negative regulator of cytokines.

Dysregulation of SOCS7 contributes to disease. Reduced expression can lead to prolonged signaling through pathways such as STAT3, promoting inflammation and tumorigenesis. Elevated expression may impair insulin signaling and contribute to metabolic imbalance. Research using SOCS7 antibody has explored its roles in autoimmune disease, cancer, and diabetes. By influencing multiple pathways, SOCS7 serves as a critical checkpoint in cellular signaling.

SOCS7 antibody is widely used in western blotting, immunohistochemistry, and immunofluorescence. Western blotting demonstrates protein abundance and post-translational modifications, immunohistochemistry highlights expression patterns in tissues such as spleen and pancreas, and immunofluorescence reveals subcellular distribution, including nuclear translocation. These applications make SOCS7 antibody an indispensable tool in signaling research.

By providing validated SOCS7 antibody reagents, NSJ Bioreagents supports studies into cytokine signaling, metabolism, and cancer biology. Detection of Suppressor of cytokine signaling 7 enables researchers to better understand how signaling feedback loops are maintained and disrupted in disease.

UniProt: O14512