Recombinant SNCA antibody

Catalog No. ABIN7882417

The Rabbit Monoclonal anti-SNCA antibody is suitable to detect SNCA in samples from Human, Mouse and Rat. It has been validated for WB, IF and IHC (p).

Quick Overview for Recombinant SNCA antibody (ABIN7882417)

Target: SNCA (Synuclein, alpha (SNCA))

Antibody Type: Recombinant Antibody

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Monoclonal

Conjugate: This SNCA antibody is un-conjugated

Application: Western Blotting (WB), Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Clone: AGA-19

Product Details anti-SNCA Antibody

Purpose: Alpha-Synuclein Antibody / SNCA

Purification: Affinity chromatography

Immunogen: A peptide sequence specific to Alpha-Synuclein was used as the immunogen for the Alpha-Synuclein antibody.

Isotype: IgG

Application Details

Application Notes: Optimal dilution of the Alpha-Synuclein antibody should be determined by the researcher.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Antibody in PBS with 0.02 % sodium azide, 50 % glycerol and 0.4-0.5 mg/mL BSA

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: After reconstitution, the Alpha-Synuclein antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

Target Details for SNCA

Target: SNCA (Synuclein, alpha (SNCA))

Alternative Name: Alpha-Synuclein

Background: Alpha-Synuclein (SCNA) is a small, soluble protein predominantly expressed in the brain, particularly in presynaptic nerve terminals. It plays a role in synaptic vesicle trafficking, neurotransmitter release regulation, and neuronal plasticity. Alpha-Synuclein can adopt different conformations, with certain aggregated forms being implicated in neurodegenerative processes.

Mutations or abnormal accumulation of Alpha-Synuclein are strongly linked to synucleinopathies, including Parkinson's disease, dementia with Lewy bodies, and multiple system atrophy. Its aggregation into insoluble fibrils is a key pathological hallmark of these conditions. Studying Alpha-Synuclein expression and distribution provides valuable insights into neuronal function, protein misfolding, and neurodegenerative disease mechanisms.

Using a high-quality Alpha-Synuclein antibody enables sensitive detection in assays such as western blot, immunohistochemistry, and ELISA. An Alpha-Synuclein antibody from NSJ Bioreagents offers reliable performance for researchers investigating protein aggregation, neurodegenerative disease progression, and potential therapeutic interventions. Selecting the appropriate Alpha-Synuclein antibody is essential for generating reproducible and accurate results in both basic and applied neuroscience research.

UniProt: P37840

Pathways: Synaptic Membrane, Regulation of G-Protein Coupled Receptor Protein Signaling, Positive Regulation of Endopeptidase Activity, Regulation of Carbohydrate Metabolic Process, Platelet-derived growth Factor Receptor Signaling, Negative Regulation of Transporter Activity, Regulation of long-term Neuronal Synaptic Plasticity