Recombinant TARDBP antibody

Catalog No. ABIN7882427

The Rabbit Monoclonal anti-TARDBP antibody (Clone 26T75) (ABIN7882427) specifically detects TARDBP in WB, IF and IHC (p). The antibody is reactive with Human, Mouse and Rat samples.

Quick Overview for Recombinant TARDBP antibody (ABIN7882427)

Target: TARDBP (TAR DNA Binding Protein (TARDBP))

Antibody Type: Recombinant Antibody

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Monoclonal

Conjugate: This TARDBP antibody is un-conjugated

Application: Western Blotting (WB), Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Clone: 26T75

Product Details anti-TARDBP Antibody

Purpose: TAR DNA binding protein 43 Antibody / TDP43 / TARDBP

Purification: Affinity chromatography

Immunogen: A peptide sequence specific to TAR DNA binding protein 43 was used as the immunogen for the TAR DNA binding protein 43 antibody.

Isotype: IgG

Application Details

Application Notes: Optimal dilution of the TAR DNA binding protein 43 antibody should be determined by the researcher.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Antibody in PBS with 0.02 % sodium azide, 50 % glycerol and 0.4-0.5 mg/mL BSA

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: After reconstitution, the TAR DNA binding protein 43 Antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

Target Details for TARDBP

Target: TARDBP (TAR DNA Binding Protein (TARDBP))

Alternative Name: TAR DNA binding protein 43

Background: TAR DNA binding protein 43 is a DNA/RNA-binding protein that shuttles between nucleus and cytoplasm to coordinate RNA metabolism. It recognizes UG-rich sequences via 2 RNA recognition motifs and uses a glycine-rich C-terminus to assemble ribonucleoprotein complexes. TAR DNA binding protein 43 regulates alternative splicing, transcript stability, 3' end processing, and mRNA transport, integrating these steps with transcription-coupled RNA handling across diverse cell types.

It participates in stress-responsive RNA granule dynamics and controlled phase behavior, linking RNA sorting to protein quality control pathways. Its nuclear enrichment, regulated export, and post-translational modification states offer quantitative readouts for studies of RNA processing, trafficking, and cellular adaptation in defined model systems.

The TAR DNA binding protein 43 antibody from NSJ Bioreagents enables specific detection of endogenous TDP-43 in applications such as western blot, immunofluorescence, immunohistochemistry, immunoprecipitation, and RNA-protein pulldown workflows. Researchers use the TAR DNA binding protein 43 antibody to measure total protein levels, assess nuclear-cytoplasmic distribution, and evaluate biochemical fractionation or stress-induced relocalization when paired with appropriate complementary reagents. With high specificity and reproducible performance, the TAR DNA binding protein 43 antibody supports rigorous analysis of RNA-binding protein networks and post-transcriptional regulation.

UniProt: Q13148

Pathways: Positive Regulation of Peptide Hormone Secretion