TNC antibody

Catalog No. ABIN7882449

This Mouse Monoclonal antibody specifically detects TNC in IHC (p). It exhibits reactivity toward Human.

Quick Overview for TNC antibody (ABIN7882449)

Target: TNC (Tenascin C (TNC))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This TNC antibody is un-conjugated

Application: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Clone: SPM319

Product Details anti-TNC Antibody

Purpose: Anti-Tenascin C Antibody

Purification: Protein G affinity chromatography

Immunogen: Human breast carcinoma cells were used as the immunogen for the anti-Tenascin C antibody.

Isotype: IgG1, kappa

Application Details

Application Notes: Optimal dilution of the anti-Tenascin C antibody should be determined by the researcher.

1. Staining of formalin-fixed tissues requires boiling tissue sections in pH 9 10 mM Tris with 1 mM EDTA for 10-20 min followed by cooling at RT for 20 min
2. The prediluted format is supplied in a dropper bottle and is optimized for use in IHC. After epitope retrieval step (if required), drip mAb solution onto the tissue section and incubate at RT for 30 min.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Prediluted in 1X PBS, 0.1 mg/mL BSA (US sourced), 0.05 % sodium azide, *For IHC use only*

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Store the anti-Tenascin C antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).

Target Details for TNC

Target: TNC (Tenascin C (TNC))

Alternative Name: Tenascin C

Background: Tenascin C is a multifunctional, disulfide-linked hexameric extracellular matrix glycoprotein expressed in association with mesenchymal epithelial interactions during development and in the neo-vasculature and stroma of undifferentiated tumors. In adults, it is restricted to certain epithelial-stromal interfaces and increases markedly in hyper-proliferative diseases and in stroma of many neoplasms, including gliomas, breast, squamous and lung carcinomas.

UniProt: P24821

Pathways: Regulation of Muscle Cell Differentiation, Regulation of Cell Size, Skeletal Muscle Fiber Development