Recombinant TCEA1 antibody

Catalog No. ABIN7882514

The Rabbit Monoclonal anti-TCEA1 antibody (Clone 29T88) (ABIN7882514) specifically detects TCEA1 in WB, IHC, IF, ICC and IP. The antibody is reactive with Human, Mouse and Rat samples.

Quick Overview for Recombinant TCEA1 antibody (ABIN7882514)

Target: TCEA1 (Transcription Elongation Factor A Protein 1 (TCEA1))

Antibody Type: Recombinant Antibody

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Monoclonal

Conjugate: This TCEA1 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF), Immunocytochemistry (ICC), Immunoprecipitation (IP)

Clone: 29T88

Product Details anti-TCEA1 Antibody

Purpose: TCEA1 Antibody / Transcription elongation factor A protein 1

Purification: Affinity chromatography

Immunogen: A synthesized peptide derived from human TCEA1 was used as the immunogen for the TCEA1 antibody.

Isotype: IgG

Application Details

Application Notes: Optimal dilution of the TCEA1 antibody should be determined by the researcher.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Rabbit IgG in phosphate buffered saline, pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol, 0.4-0.5 mg/mL BSA

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store the TCEA1 antibody at -20oC.

Target Details for TCEA1

Target: TCEA1 (Transcription Elongation Factor A Protein 1 (TCEA1))

Alternative Name: TCEA1

Background: TCEA1 antibody detects Transcription elongation factor A protein 1, encoded by the TCEA1 gene. Transcription elongation factor A protein 1 is a key regulator of RNA polymerase II transcriptional elongation and RNA processing. TCEA1 antibody provides researchers with a specific reagent to study transcriptional control, gene expression regulation, and cellular responses to DNA damage.

Transcription elongation factor A protein 1 enhances the activity of RNA polymerase II by stimulating transcript elongation and resolving transcriptional arrest. Research using TCEA1 antibody has shown that it acts as a transcriptional cofactor by interacting with paused polymerase complexes and promoting the resumption of RNA synthesis. This activity ensures efficient transcription of protein coding genes, supporting diverse cellular processes including growth, proliferation, and differentiation.

Studies with TCEA1 antibody have revealed that this factor also contributes to transcription coupled DNA repair. When RNA polymerase II encounters DNA damage, TCEA1 facilitates backtracking of the polymerase, enabling access for repair enzymes. This role links transcriptional regulation with genome stability and provides a mechanism for protecting cells from genotoxic stress. Dysregulation of this pathway may impair DNA repair capacity and promote disease development.

Beyond transcriptional elongation, Transcription elongation factor A protein 1 influences chromatin remodeling. Research using TCEA1 antibody has demonstrated that it cooperates with other transcriptional cofactors to modify chromatin architecture, enhancing promoter clearance and elongation efficiency. This highlights its integration into a broader regulatory network that coordinates transcription with chromatin state.

Dysregulation of TCEA1 expression has been implicated in cancer and neurological disease. Studies with TCEA1 antibody have shown that altered levels can disrupt transcription fidelity, impair DNA repair, and promote genomic instability. Overexpression in some cancers may provide tumor cells with enhanced transcriptional capacity, while deficiencies have been linked to neurodegeneration. These findings underscore its importance in both health and pathology.

TCEA1 antibody is commonly applied in western blotting, immunohistochemistry, and chromatin immunoprecipitation. Western blotting detects protein expression levels, immunohistochemistry reveals nuclear localization in tissue, and chromatin immunoprecipitation maps binding to actively transcribed genes. These applications make TCEA1 antibody indispensable for transcription biology research.

By supplying validated TCEA1 antibody reagents, NSJ Bioreagents supports studies into transcription elongation, DNA repair, and disease mechanisms. Detection of Transcription elongation factor A protein 1 provides insight into how cells maintain transcriptional integrity and genome stability.

UniProt: P23193