Recombinant SEC62 antibody

Catalog No. ABIN7882545

This Rabbit Monoclonal antibody specifically detects SEC62 in WB, IHC, IF and ICC. It exhibits reactivity toward Human, Mouse and Rat.

Quick Overview for Recombinant SEC62 antibody (ABIN7882545)

Target: SEC62 (TLOC1) (Translocation Protein 1 (TLOC1))

Antibody Type: Recombinant Antibody

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Monoclonal

Conjugate: This SEC62 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF), Immunocytochemistry (ICC)

Clone: 31S64

Product Details anti-SEC62 Antibody

Purpose: SEC62 Antibody / Translocation protein SEC62

Purification: Affinity chromatography

Immunogen: A synthesized peptide derived from human SEC62 was used as the immunogen for the SEC62 antibody.

Isotype: IgG

Application Details

Application Notes: Optimal dilution of the SEC62 antibody should be determined by the researcher.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Rabbit IgG in phosphate buffered saline, pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol, 0.4-0.5 mg/mL BSA

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store the SEC62 antibody at -20oC.

Target Details for SEC62

Target: SEC62 (TLOC1) (Translocation Protein 1 (TLOC1))

Alternative Name: SEC62

Background: SEC62 antibody detects Translocation protein SEC62, encoded by the SEC62 gene. Translocation protein SEC62 is an endoplasmic reticulum membrane protein that functions as part of the SEC61-SEC62-SEC63 complex required for posttranslational translocation of proteins into the endoplasmic reticulum. SEC62 antibody provides researchers with a specific reagent for investigating protein translocation, endoplasmic reticulum biology, and disease processes associated with protein trafficking.

Translocation protein SEC62 cooperates with the SEC61 channel and SEC63 cochaperone to mediate insertion of polypeptides into the endoplasmic reticulum lumen. Research using SEC62 antibody has shown that it functions particularly in the import of short signal peptide proteins and stress-inducible proteins. This activity helps maintain proteostasis under conditions of cellular stress, ensuring that unfolded or newly synthesized proteins are efficiently imported and processed.

Studies with SEC62 antibody have revealed that the protein also contributes to the unfolded protein response and endoplasmic reticulum stress adaptation. By regulating the influx of client proteins, Translocation protein SEC62 limits accumulation of misfolded proteins and protects cells from apoptosis. These findings underscore its protective role in maintaining endoplasmic reticulum homeostasis.

In cancer biology, overexpression of SEC62 has been identified in lung, prostate, and thyroid cancers. Research using SEC62 antibody has demonstrated that elevated expression enhances stress tolerance, migration, and invasion, linking the protein to aggressive tumor phenotypes. Because of these properties, SEC62 is being explored as a prognostic biomarker and therapeutic target in oncology.

SEC62 antibody is widely used in western blotting, immunohistochemistry, and immunofluorescence. Western blotting detects SEC62 expression under stress conditions, immunohistochemistry highlights localization to the endoplasmic reticulum in tissues, and immunofluorescence shows its membrane association with endoplasmic reticulum structures. These applications make SEC62 antibody an important reagent in cell biology and disease research.

By supplying validated SEC62 antibody reagents, NSJ Bioreagents supports studies into endoplasmic reticulum function, protein translocation, and cancer. Detection of Translocation protein SEC62 provides insight into how cells regulate protein import under both normal and pathological conditions.

UniProt: Q99442