Recombinant TMEM67 antibody

Catalog No. ABIN7882553

The Rabbit Monoclonal anti-TMEM67 antibody (Clone 30T77) (ABIN7882553) specifically detects TMEM67 in WB, IF, IHC, FACS and ICC. The antibody is reactive with Human, Mouse and Rat samples.

Quick Overview for Recombinant TMEM67 antibody (ABIN7882553)

Target: TMEM67 (Transmembrane Protein 67 (TMEM67))

Antibody Type: Recombinant Antibody

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Monoclonal

Conjugate: This TMEM67 antibody is un-conjugated

Application: Western Blotting (WB), Immunofluorescence (IF), Immunohistochemistry (IHC), Flow Cytometry (FACS), Immunocytochemistry (ICC)

Clone: 30T77

Product Details anti-TMEM67 Antibody

Purpose: TMEM67 Antibody / Meckelin

Purification: Affinity-chromatography

Immunogen: A synthesized peptide derived from human Meckelin was used as the immunogen for the TMEM67 antibody.

Isotype: IgG

Application Details

Application Notes: Optimal dilution of the TMEM67 antibody should be determined by the researcher.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Rabbit IgG in phosphate buffered saline, pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol, 0.4-0.5 mg/mL BSA

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store the TMEM67 antibody at -20oC.

Target Details for TMEM67

Target: TMEM67 (Transmembrane Protein 67 (TMEM67))

Alternative Name: TMEM67

Background: TMEM67 antibody detects meckelin, a transmembrane protein encoded by the TMEM67 gene. Meckelin localizes to primary cilia and the plasma membrane, where it contributes to ciliary structure and signaling. Mutations in TMEM67 cause Meckel syndrome type 3 and Joubert syndrome type 6, autosomal recessive ciliopathies characterized by developmental abnormalities, cystic kidneys, and neurological defects. Meckelin is therefore essential for cilia based signaling pathways, including Wnt and Hedgehog.

TMEM67 antibody is widely applied in developmental biology, nephrology, and neurogenetics. By detecting meckelin, researchers can study how ciliary proteins regulate organ development and signaling. Ciliary dysfunction underlies a spectrum of disorders known as ciliopathies, linking TMEM67 research to human disease mechanisms.

Western blot assays detect meckelin in tissue lysates, while immunohistochemistry maps expression in kidney, brain, and liver. Immunofluorescence highlights punctate staining at primary cilia, consistent with its functional localization. These applications provide robust tools for examining ciliary protein biology.

Meckelin plays roles in regulating planar cell polarity, neuronal migration, and renal morphogenesis. Its dysfunction disrupts signaling and tissue organization, causing developmental defects and organ pathology. By applying TMEM67 antibody, scientists can investigate pathways linking ciliary function to embryogenesis, neurodevelopment, and kidney disease.

TMEM67 antibody from NSJ Bioreagents delivers dependable specificity for studying meckelin function. Its strong performance ensures accurate detection across developmental and disease contexts.

UniProt: Q5HYA8