Tyrosinase-Related Protein 1 antibody

Catalog No. ABIN7882609

The Rabbit Polyclonal anti-Tyrosinase-Related Protein 1 antibody is suitable to detect Tyrosinase-Related Protein 1 in samples from Human. It has been validated for IHC (p).

Quick Overview for Tyrosinase-Related Protein 1 antibody (ABIN7882609)

Target: Tyrosinase-Related Protein 1 (TYRP1)

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Tyrosinase-Related Protein 1 antibody is un-conjugated

Application: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Product Details anti-Tyrosinase-Related Protein 1 Antibody

Purpose: Tyrosinase-Related Protein-1 Antibody / TRP1 / TYRP1

Purification: Protein A affinity

Immunogen: Recombinant human TYRP1 protein was used as the immunogen for the Tyrosinase-Related Protein-1 antibody.

Isotype: IgG

Application Details

Application Notes: Optimal dilution of the Tyrosinase-Related Protein-1 antibody should be determined by the researcher.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.2 mg/mL

Buffer: 0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced), 0.05 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Aliquot the Tyrosinase-Related Protein-1 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

Target Details for Tyrosinase-Related Protein 1

Target: Tyrosinase-Related Protein 1 (TYRP1)

Alternative Name: Tyrosinase-Related Protein-1

Background: It reacts with a 75 kDa melanocyte-specific gene product, identified as Tyrosinase-related protein-1 (TRP-1). It is involved in melanin synthesis. TRP1 is present on the melanosomal membranes of melanoma, normal melanocytes and nevi.Recent evidence suggests that TRP-1 is involved in maintaining stability of tyrosinase protein and modulating its catalytic activity. TRP-1 is also involved in maintenance of melanosome ultrastructure and affects melanocyte proliferation and cell death.

UniProt: P17643