YY1 antibody

Catalog No. ABIN7882715

The Mouse Monoclonal anti-YY1 antibody (Clone YY1-5436) (ABIN7882715) specifically detects YY1 in WB and IHC (p). The antibody is reactive with Human samples.

Quick Overview for YY1 antibody (ABIN7882715)

Target: YY1 (YY1 Transcription Factor (YY1))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This YY1 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Clone: YY1-5436

Product Details anti-YY1 Antibody

Purpose: YY1 Antibody / Ying-Yang 1

Purification: Protein A/G affinity

Immunogen: A His-tagged YY1 protein was used as the immunogen for the YY1 antibody.

Isotype: IgG2, kappa

Application Details

Application Notes: Optimal dilution of the YY1 antibody should be determined by the researcher.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.2 mg/mL

Buffer: 0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced), 0.05 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Aliquot the YY1 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

Target Details for YY1

Target: YY1 (YY1 Transcription Factor (YY1))

Alternative Name: YY1

Background: The YY1 transcription factor, also known as NF-E1 (human) and Delta or UCRBP (mouse) is of interest due to its diverse effects on a wide variety of target genes. YY1 is broadly expressed in a wide range of cell types and contains four C-terminal zinc finger motifs of the Cys-Cys-His-His type and an unusual set of structural motifs at its N-terminal end. It binds to downstream elements in several vertebrate ribosomal protein genes, where it apparently acts positively to stimulate transcription and can act either negatively or positively in the context of the immunoglobulin k 3' enhancer and immunoglobulin heavy-chain i 1/2E1 site as well as the P5 promoter of the adenoassociated virus. It thus appears that YY1 is a bifunctional protein, capable of functioning as an activator in some transcriptional control elements and a repressor in others.

UniProt: P25490