Zona Pellucida Glycoprotein 3 antibody

Catalog No. ABIN7882734

This Rabbit Polyclonal antibody specifically detects Zona Pellucida Glycoprotein 3 in WB. It exhibits reactivity toward Human.

Quick Overview for Zona Pellucida Glycoprotein 3 antibody (ABIN7882734)

Target: Zona Pellucida Glycoprotein 3 (ZP3)

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Zona Pellucida Glycoprotein 3 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-Zona Pellucida Glycoprotein 3 Antibody

Purpose: ZP3 Antibody / Zona pellucida glycoprotein 3

Sequence: LRLMEENWNA EKRSPTFHLG DAAHLQAEIH T

Purification: Antigen affinity purified

Immunogen: Amino acids LRLMEENWNAEKRSPTFHLGDAAHLQAEIHT from the human protein were used as the immunogen for the ZP3 antibody.

Isotype: IgG

Application Details

Application Notes: Optimal dilution of the ZP3 antibody should be determined by the researcher.

Restrictions: For Research Use only

Handling

Format: Lyophilized

Buffer: 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water

Storage: 4 °C,-20 °C

Storage Comment: After reconstitution, the ZP3 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

Target Details for Zona Pellucida Glycoprotein 3

Target: Zona Pellucida Glycoprotein 3 (ZP3)

Alternative Name: ZP3

Background: Zona pellucida sperm-binding protein 3, also known as zona pellucida glycoprotein 3 (Zp-3) or the sperm receptor, is a ZP module-containing protein that in humans is encoded by the ZP3 gene. It is mapped to 7q11.23. he zona pellucida is an extracellular matrix that surrounds the oocyte and early embryo. It is composed primarily of three or four glycoproteins with various functions during fertilization and preimplantation development. The protein encoded by this gene is a structural component of the zona pellucida and functions in primary binding and induction of the sperm acrosome reaction. The nascent protein contains a N-terminal signal peptide sequence, a conserved ZP domain, a C-terminal consensus furin cleavage site, and a transmembrane domain. It is hypothesized that furin cleavage results in release of the mature protein from the plasma membrane for subsequent incorporation into the zona pellucida matrix. However, the requirement for furin cleavage in this process remains controversial based on mouse studies. A variation in the last exon of this gene has previously served as the basis for an additional ZP3 locus, however, sequence and literature review reveals that there is only one full-length ZP3 locus in the human genome. Another locus encoding a bipartite transcript designated POMZP3 contains a duplication of the last four exons of ZP3, including the above described variation, and maps closely to this gene.

UniProt: P21754

Pathways: Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process