Cadherin 13 antibody (Extracellular, N-Term)

Catalog No. ABIN7884804

This Rabbit Polyclonal antibody specifically detects Cadherin 13 in WB and LCI. It exhibits reactivity toward Human, Mouse and Rat.

Quick Overview for Cadherin 13 antibody (Extracellular, N-Term) (ABIN7884804)

Target: Cadherin 13 (CDH13)

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Cadherin 13 antibody is un-conjugated

Application: Western Blotting (WB), Live Cell Imaging (LCI)

Grade: Carrier-free

Product Details anti-Cadherin 13 Antibody

Binding Specificity: AA 164-178, Extracellular, N-Term

Purpose: A rabbit polyclonal antibody to Cadherin-13 (extracellular)

Predicted Reactivity: Rat - identical.  Human - 14 out of 15 amino acid residues identical.

Purification: Affinity purified on immobilized antigen.

Immunogen: (C)DSDRPEGSKFRLTGK, corresponding to amino acid residues 164 - 178 of mouse CDH13

Isotype: IgG

Application Details

Application Notes: The optimal concentration should be determined by the user

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: 0.2 mL double distilled water (DDW).

Concentration: 1 mg/mL

Buffer: PBS pH 7.4

Preservative: Without preservative

Storage: -20 °C

Storage Comment: The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20°C

Target Details for Cadherin 13

Target: Cadherin 13 (CDH13)

Alternative Name: CDH13

Background:

Synonyms: CDH13, Heart Cadherin, H-Cadherin, Truncated Cadherin, T-Cadherin, T-Cad

Description:

Cadherin-13 (CDH13), also known as Heart Cadherin (H-Cadherin) or Truncated Cadherin (T-cadherin), is a member of the cadherin superfamily, a group of calcium-dependent cell adhesion molecules integral to various cellular processes, including tissue development and maintenance.1

Unlike classical cadherins, which are type I membrane proteins that span the cell membrane once, Cadherin-13 is anchored to the cell membrane by a glycosylphosphatidylinositol (GPI)-anchor, making it an atypical cadherin.1,2

Cadherin-13 is predominantly expressed in the nervous system, where it regulates neuronal migration, axon growth, and synaptic connectivity during brain development. It mediates cell adhesion through homophilic interactions, meaning it binds to other Cadherin-13 Molecules on adjacent cells. This adhesive property is crucial for maintaining the structural integrity of neural circuits and facilitating proper brain function.2,3

Alterations in Cadherin-13 expression or function have been linked to various neurodevelopmental and psychiatric disorders, including attention-deficit/hyperactivity disorder (ADHD), autism spectrum disorder, and schizophrenia. These associations underscore the critical role of Cadherin-13 in brain function and behavior.3,4

Beyond the nervous system, Cadherin-13 has been implicated in metabolic regulation. It serves as a binding protein for high molecular weight isoforms of adiponectin, an adipose-derived hormone with anti-inflammatory and insulin-sensitizing properties. This interaction is essential for mediating adiponectin's effects on metabolic processes and vascular function.3,5,6

Finally, Cadherin-13 expression is often downregulated in various cancers, including colon and prostate cancers. This downregulation is associated with increased invasive and metastatic potential of tumor cells and poorer prognosis, indicating that Cadherin-13 may function as a tumor suppressor.7

Gene ID: 12554

UniProt: Q9WTR5

Pathways: EGFR Signaling Pathway, Cell-Cell Junction Organization