GRM2 antibody (Extracellular, N-Term)

Catalog No. ABIN7885060

The Rabbit Polyclonal anti-GRM2 antibody is suitable to detect GRM2 in samples from Human, Rat and Mouse. It has been validated for WB, IHC, IF, IC and LCI.

Quick Overview for GRM2 antibody (Extracellular, N-Term) (ABIN7885060)

Target: GRM2 (Glutamate Receptor, Metabotropic 2 (GRM2))

Reactivity: Human, Rat, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This GRM2 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF), Immunochromatography (IC), Live Cell Imaging (LCI)

Grade: Carrier-free

Product Details anti-GRM2 Antibody

Binding Specificity: Extracellular, N-Term

Purpose: A Rabbit Polyclonal Antibody to Metabotropic Glutamate Receptor 2

Predicted Reactivity: Mouse,human,dog,monkey - identical

Purification: Affinity purified on immobilized antigen.

Immunogen: SLSRGADGSRHIC, corresponding to amino acids 109-121 of rat mGluR2

Isotype: IgG

Application Details

Application Notes:

WB: 1:200-1:400

FC: The optimal concentration should be determined by the user

ICC: 1:100

IHC: The optimal concentration should be determined by the user

IP: The optimal concentration should be determined by the user

Comment:

Negative Control: (ABIN7235685)

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: 0.2 mL double distilled water (DDW)

Concentration: 1 mg/mL

Buffer: PBS pH 7.4

Preservative: Without preservative

Storage: -20 °C

Storage Comment: The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20°C

Target Details for GRM2

Target: GRM2 (Glutamate Receptor, Metabotropic 2 (GRM2))

Alternative Name: Metabotropic glutamate receptor 2

Background:

Synonyms: Metabotropic glutamate receptor 2, GRM2, mGlu2, GPRC1B

Description: L-Glutamate, the major excitatory neurotransmitter in the central nervous system, operates through several receptors that are categorized as ionotropic (ligand-gated cation channels) or metabotropic (G-protein coupled receptors). The metabotropic glutamate receptor family includes eight members (mGluR1-8) that have been divided into three groups based on their sequence homology, pharmacology and signal transduction.Group II of the metabotropic glutamate receptors includes the mGluR2 and mGluR3 receptors. The receptors present the typical G-protein coupled receptor (GPCR) signature topology: seven transmembrane domains with a large extracellular N-terminus domain that contains the glutamate binding site, and an intracellular C-terminus.1,2 mGluR2 and mGluR3 are coupled to Gi/Go and hence inhibit cAMP formation following receptor activation.1,2mGluR2 is widely distributed throughout the brain with high expression in several limbic areas including the cortex, hippocampus and amygdala. mGluR2 is localized primarily presynaptically, although postsynaptic localization has also been described.In line with its presynaptic localization, mGluR2 is thought to function as an autoreceptor in a negative feedback mechanism that suppress further release of glutamate from the cell on which it is expressed.The involvement of mGluR2 in neuronal excitability and synaptic transmission suggests that modulation of this receptor is a promising strategy for the treatment of neurological and neuropsychiatric disorders such as anxiety, schizophrenia, and pain.3

Gene ID: 24415

UniProt: P31421

Pathways: cAMP Metabolic Process, Dicarboxylic Acid Transport