Neuregulin 2 antibody (Extracellular, N-Term)

Catalog No. ABIN7885164

This Rabbit Polyclonal antibody specifically detects Neuregulin 2 in WB, IHC and IF. It exhibits reactivity toward Rat and Mouse.

Quick Overview for Neuregulin 2 antibody (Extracellular, N-Term) (ABIN7885164)

Target: Neuregulin 2 (NRG2)

Reactivity: Rat, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Neuregulin 2 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)

Grade: Carrier-free

Product Details anti-Neuregulin 2 Antibody

Binding Specificity: AA 297-311, Extracellular, N-Term

Purpose: A Rabbit Polyclonal Antibody to Neuregulin-2

Predicted Reactivity: Mouse,human - identical

Purification: Affinity purified on immobilized antigen.

Immunogen: (C)RDIRIKYGNGRKNSR, corresponding to amino acid residues 297-311 of rat Neuregulin-2

Isotype: IgG

Application Details

Application Notes:

WB: 1:200

FC: The optimal concentration should be determined by the user

ICC: The optimal concentration should be determined by the user

IHC: 1:300

IP: The optimal concentration should be determined by the user

Comment:

Negative Control: (ABIN7236030)

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: 0.2 mL double distilled water (DDW)

Concentration: 1 mg/mL

Buffer: PBS pH 7.4

Preservative: Without preservative

Storage: -20 °C

Storage Comment: The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20°C

Target Details for Neuregulin 2

Target: Neuregulin 2 (NRG2)

Alternative Name: Neuregulin-2

Background:

Synonyms: Neuregulin-2, Pro-neuregulin-2 membrane-bound isoform, Pro-NRG2, Neural- and thymus-derived activator for ErbB kinases, NTAK

Description: Neuregulins (NRGs) are a multi member protein family involved in cell to cell communication. This family includes four human neuregulin paralogs NRG1-NRG4 which produce multiple isoforms through alternative splicing.NRGs are involved in several physiological processes including heart and peripheral nervous system development. They act in part by binding to the extracellular region of ErbB/HER transmembrane tyrosine kinases, leading to receptor dimerization and ultimately to the activation of a complex network of downstream signaling events1,2.NRG2 transcript levels markedly increase following birth, suggesting that NRG2 has important functions in the postnatal and adult brain. Several studies have also shown that NRG2 modulates glutamatergic transmission in GABAergic neurons and selectively affects GluN2B-containing NMDA receptors2,3.The region containing the NRG2 locus is associated with schizophrenia and other psychiatric disorders and genetically linked to ADHD in genome-wide scans2.

Gene ID: 432361

UniProt: O35569

Pathways: RTK Signaling, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway