Serotonin Receptor 1A antibody (3rd Intracellular Loop)

Catalog No. ABIN7885388

The Rabbit Polyclonal anti-Serotonin Receptor 1A antibody (ABIN7885388) specifically detects Serotonin Receptor 1A in WB, IHC and IF. The antibody is reactive with Rat and Mouse samples.

Quick Overview for Serotonin Receptor 1A antibody (3rd Intracellular Loop) (ABIN7885388)

Target: Serotonin Receptor 1A (HTR1A)

Reactivity: Rat, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Serotonin Receptor 1A antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)

Grade: Carrier-free

Product Details anti-Serotonin Receptor 1A Antibody

Binding Specificity: 3rd Intracellular Loop, AA 251-266

Purpose: A Rabbit Polyclonal Antibody to 5-Hydroxytryptamine Receptor 1A

Predicted Reactivity: Mouse - identical

Purification: Affinity purified on immobilized antigen.

Immunogen: KKSLNGQPGSGDWRRC, corresponding to amino acid residues 251-266 of rat 5-Hydroxytryptamine receptor 1A

Isotype: IgG

Application Details

Application Notes:

WB: 1:200

FC: The optimal concentration should be determined by the user

ICC: The optimal concentration should be determined by the user

IHC: 1:100

IP: The optimal concentration should be determined by the user

Comment:

Negative Control: (ABIN7236780)

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: 0.2 mL double distilled water (DDW)

Concentration: 1 mg/mL

Buffer: PBS pH 7.4

Preservative: Without preservative

Storage: -20 °C

Storage Comment: The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20°C

Target Details for Serotonin Receptor 1A

Target: Serotonin Receptor 1A (HTR1A)

Alternative Name: 5-Hydroxytryptamine receptor 1A

Background:

Synonyms: 5-Hydroxytryptamine receptor 1A, Serotonin receptor 1A

Description: Serotonin (5-hydroxytryptamine, 5-HT1) is an important neurotransmitter in the central nervous system (CNS) that exerts its neuronal activity via 5-HT receptors.5-HT receptors are subdivided into seven families termed 5-HT1 through 5-HT7.1 The 5-HT receptor families belong to the G-protein coupled receptor superfamily with the exception of 5-HT3 receptor class which belongs to the ligand-gated ion channels.2The 5-HT1 receptor class comprises of five different receptors (5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E and 5-HT1F) which share 41-63 % overall sequence identity and couple preferentially to Gi/Go to inhibit cAMP formation.2The 5-HT1A receptor is the most widespread of all the 5-HT receptors. In the CNS, 5-HT1A receptors exist in the cerebral cortex, hippocampus, septum, amygdala and raphe nucelus in high densities, and was also demonstrated in a variety of tissues from various species.2,3 Activation of 5-HT1A receptor decreases blood pressure and heart rate, and is involved in learning, memory, relieving anxiety and depression.1,4

Gene ID: 24473

UniProt: P19327

Pathways: JAK-STAT Signaling, Synaptic Membrane, Feeding Behaviour