Tetraspanin 3 antibody (Extracellular, Loop 2)

Catalog No. ABIN7885572

This Rabbit Polyclonal antibody specifically detects Tetraspanin 3 in WB, IHC, FACS and LCI. It exhibits reactivity toward Human, Mouse and Rat.

Quick Overview for Tetraspanin 3 antibody (Extracellular, Loop 2) (ABIN7885572)

Target: Tetraspanin 3 (TSPAN3)

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Tetraspanin 3 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC), Flow Cytometry (FACS), Live Cell Imaging (LCI)

Grade: Carrier-free

Product Details anti-Tetraspanin 3 Antibody

Binding Specificity: AA 155-169, Extracellular, Loop 2

Purpose: A Rabbit Polyclonal antibody to Tetraspanin-3 (extracellular)

Predicted Reactivity: Mouse,rat - identical

Purification: Affinity purified on immobilized antigen.

Immunogen: (C)DWENTDWFKETKNQS, corresponding to amino acid residues 155 - 169 of human Tetraspanin-3

Isotype: IgG

Application Details

Application Notes:

WB: 1:200-1:400

FC: 2.5 μg per reaction

ICC: The optimal concentration should be determined by the user

IHC: 1:300

IP: The optimal concentration should be determined by the user

Comment:

Negative Control: (ABIN7237377)

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: 0.2 mL double distilled water (DDW)

Concentration: 1 mg/mL

Buffer: PBS pH 7.4

Preservative: Without preservative

Storage: -20 °C

Storage Comment: The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20°C

Target Details for Tetraspanin 3

Target: Tetraspanin 3 (TSPAN3)

Alternative Name: TSPAN3

Background:

Synonyms: TSPAN3, Transmembrane 4 Superfamily Member 8, TM4SF8

Description: Tetraspanin-3, encoded by TSPAN3 gene is a membrane-spanning glycoprotein that has a role in cell migration, proliferation, and interactions between cells and extracellular matrix.As suggested by the family name, TSPANs are categorized by the presence of four trans-membrane domains, of which two are extracellular. The intracellular part includes the C and N terminal domains that can facilitate protein-protein interactions, as well as guide intracellular trafficking. TSPANs have multiple roles In the immune and vascular systems, and they act as organizers of functional microdomains and multi-subunit receptor complexes 1.Tspan3 is highly expressed in the brain and elevated in brains of Alzheimers disease (AD) patients. It was shown to interact with ADAM10, which is a marker for Alzheimer's disease 2. It was also shown to be expressed by dendritic cells (DCs) which suggests that it may be involved in the function of DCs in association with T cell stimulation 3.Its functional diversity and importance for the development and onset of various diseases makes Tetraspanin 3 an appealing research target.

Gene ID: 10099

UniProt: O60637