TMEM108 antibody (Extracellular Loop)

Catalog No. ABIN7885615

The Rabbit Polyclonal anti-TMEM108 antibody is suitable to detect TMEM108 in samples from Human, Mouse and Rat. It has been validated for WB, FACS, IHC and LCI.

Quick Overview for TMEM108 antibody (Extracellular Loop) (ABIN7885615)

Target: TMEM108 (Transmembrane Protein 108 (TMEM108))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This TMEM108 antibody is un-conjugated

Application: Western Blotting (WB), Flow Cytometry (FACS), Immunohistochemistry (IHC), Live Cell Imaging (LCI)

Product Details anti-TMEM108 Antibody

Binding Specificity: AA 208-223, Extracellular Loop

Purpose: A Rabbit Polyclonal Antibody to TMEM108 (Extracellular)

Predicted Reactivity: Rat,mouse - 15 out of 16 amino acid residues identical.

Purification: Affinity purified on immobilized antigen.

Immunogen: (C)GQKRPLGKIFQIYKGN, corresponding to amino acid residues 208 - 223 of human TMEM108

Isotype: IgG

Application Details

Application Notes: The optimal concentration should be determined by the user

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: 25 μL, 50 μL or 0.2 mL double distilled water (DDW), depending on the sample size.

Concentration: 0.8 mg/mL

Buffer: PBS pH 7.4, 1 % BSA with 0.05 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20°C

Target Details for TMEM108

Target: TMEM108 (Transmembrane Protein 108 (TMEM108))

Alternative Name: TMEM108

Background:

Synonyms: Transmembrane Protein 108, Retrolinkin, RTLN

Description:

TMEM108 (Transmembrane Protein 108) is a transmembrane protein originally identified as Retrolinkin, a protein involved in retrograde axon transport in the brain.1

TMEM108 is predominantly expressed in the brain where it has roles in neural connectivity and plasticity.

Indeed, TMEM108 has garnered attention in neuropsychiatric research due to its involvement in several cellular processes critical for proper brain function. A growing body of evidence links TMEM108 dysregulation to a range of neuropsychiatric disorders, including schizophrenia, bipolar disorder and major depressive disorder (MDD).2,3

TMEM108 plays a role in dendritic spine formation and synaptic transmission in neurons. Abnormalities in these processes can disrupt neural circuitry, which is a common feature in neuropsychiatric conditions. Disrupted synaptic connectivity has been implicated in the cognitive and behavioral symptoms observed in disorders such as schizophrenia.4,5

Beyond neurons, TMEM108 is expressed in oligodendrocytes and their precursors. Impaired oligodendrocyte function and myelin integrity can affect signal propagation along axons, potentially contributing to the white matter abnormalities frequently reported in psychiatric disorders. This dual role in both neuronal and glial cells positions TMEM108 as a key factor in maintaining overall brain network integrity.6

Given its multifaceted role in brain physiology, TMEM108 is being investigated as a potential biomarker for early diagnosis and prognosis in neuropsychiatric disorders. Understanding its function could also pave the way for developing targeted therapies aimed at restoring synaptic and myelin integrity.

Gene ID: 66000

UniProt: Q6UXF1