Recombinant BCL6 antibody

Catalog No. ABIN7938057

The Rabbit Monoclonal anti-BCL6 antibody (Clone 3K6) (ABIN7938057) specifically detects BCL6 in WB. The antibody is reactive with Human and Mouse samples.

Quick Overview for Recombinant BCL6 antibody (ABIN7938057)

Target: BCL6 (B-Cell CLL/lymphoma 6 (BCL6))

Antibody Type: Recombinant Antibody

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Monoclonal

Conjugate: This BCL6 antibody is un-conjugated

Application: Western Blotting (WB)

Clone: 3K6

Product Details anti-BCL6 Antibody

Purpose: BCL6 antibody (rAb), 100 μg (Clone 3K6)

Purification: Protein A Chromatography

Immunogen: This antibody was raised against the BCL6 fusion protein.

Isotype: IgG

Application Details

Application Notes: WB: 1:5000-1:50000 dilution

Restrictions: For Research Use only

Handling

Buffer: Purified IgG in PBS, pH 7.3, with 50 % glycerol and 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze/thaw cycles by aliquoting items into single-use fractions,Keep all reagents on ice when not in storage

Storage: -20 °C

Storage Comment: Some products may be shipped at room temperature. This will not affect their stability or performance. Avoid repeated freeze/thaw cycles by aliquoting items into single-use fractions for storage at -20°C for up to 2 years. Keep all reagents on ice when not in storage.

Expiry Date: 24 months

Target Details for BCL6

Target: BCL6 (B-Cell CLL/lymphoma 6 (BCL6))

Alternative Name: BCL6

Background:

Background_Plain: BCL6, a zinc finger transcription factor, contains an N-terminal BTB/POZ domain and C-terminal zinc finger DNA-binding motifs and represses transcription of a wide range of target proteins and microRNAs. BCL6 protein has been reported as a master regulator of B lymphocyte development and growth and altered BCL6 protein expression was implicated in pathogenesis of diverse human hematologic malignancies, especially in the diffuse large B cell lymphoma (DLBCL). BCL6 is required for the development of T follicular helper T cells (TFH), a helper T cell subset required for the formation of mature and productive GCs. BCL6 has also been shown to play important regulatory roles in macrophages.

Aliases: B-Cell CLL/Lymphoma 6, BCL5, LAZ3, BCL6A, ZNF51, ZBTB27

Molecular Weight: 79 kDa

Pathways: Chromatin Binding, Regulation of Leukocyte Mediated Immunity, Production of Molecular Mediator of Immune Response, Protein targeting to Nucleus