Histone H2A antibody (C-Term)

Catalog No. ABIN7938171

The Rat Monoclonal anti-Histone H2A antibody (Clone 1H11-11) (ABIN7938171) specifically detects Histone H2A in WB. The antibody is reactive with Human samples.

Quick Overview for Histone H2A antibody (C-Term) (ABIN7938171)

Target: Histone H2A

Reactivity: Human

Host: Rat

Clonality: Monoclonal

Conjugate: This Histone H2A antibody is un-conjugated

Application: Western Blotting (WB)

Clone: 1H11-11

Product Details anti-Histone H2A Antibody

Binding Specificity: C-Term

Purpose: Histone H2A.Z.2.2 antibody (mAb) (Clone 1H11-11), sample

Purification: Protein G Chromatography

Immunogen: This antibody was raised against a peptide within the C-terminal region of human Histone H2A.Z.2.2.

Isotype: IgG1

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Buffer: Purified IgG in PBS with 30 % glycerol and 0.035 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze/thaw cycles by aliquoting items into single-use fractions,Keep all reagents on ice when not in storage

Storage: -20 °C

Storage Comment: Some products may be shipped at room temperature. This will not affect their stability or performance. Avoid repeated freeze/thaw cycles by aliquoting items into single-use fractions for storage at -20°C for up to 2 years. Keep all reagents on ice when not in storage.

Expiry Date: 24 months

Target Details for Histone H2A

Target: Histone H2A

Alternative Name: Histone H2A.

Background: Histone H2A.Z (H2A Histone Family, Member V) is a histone H2A variant, a protein similar to canonical H2A but with different molecular identity and unique functions. H2A.Z is highly conserved during evolution. It plays an important role in basic cellular mechanisms such as gene activation, chromosome segregation, heterochromatic silencing and progression through the cell cycle. H2A.Z is acetylated at multiple lysine residues in its amino terminus, which may serve to allow H2A.Z to function as an insulator of chromatin domains. In the case of H2A.Z.2.2, this variant has been shown to be responsible for destabilization of the nucleosome through the chaperone complexes TIP60 and SRCAP.

Molecular Weight: 12 kDa

NCBI Accession: NP_619541