Recombinant MSH3 antibody

Catalog No. ABIN7938356

The Rabbit Monoclonal anti-MSH3 antibody is suitable to detect MSH3 in samples from Human and Rat. It has been validated for WB.

Quick Overview for Recombinant MSH3 antibody (ABIN7938356)

Target: MSH3 (MutS Homolog 3 (MSH3))

Antibody Type: Recombinant Antibody

Reactivity: Human, Rat

Host: Rabbit

Clonality: Monoclonal

Conjugate: This MSH3 antibody is un-conjugated

Application: Western Blotting (WB)

Clone: 1J23

Product Details anti-MSH3 Antibody

Purpose: MSH3 antibody (rAb), 100 μg (Clone 1J23)

Purification: Protein A Chromatography

Immunogen: This antibody was raised against the MSH3 fusion protein.

Isotype: IgG

Application Details

Application Notes: WB: 1:5000-1:10000 dilution

Restrictions: For Research Use only

Handling

Buffer: Purified IgG in PBS, pH 7.3, with 50 % glycerol and 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze/thaw cycles by aliquoting items into single-use fractions,Keep all reagents on ice when not in storage

Storage: -20 °C

Storage Comment: Some products may be shipped at room temperature. This will not affect their stability or performance. Avoid repeated freeze/thaw cycles by aliquoting items into single-use fractions for storage at -20°C for up to 2 years. Keep all reagents on ice when not in storage.

Expiry Date: 24 months

Target Details for MSH3

Target: MSH3 (MutS Homolog 3 (MSH3))

Alternative Name: MSH3

Background:

Background_Plain: MSH3 is a DNA mismatch repair (MMR) gene that heterodimerizes with MSH2 to form MutS beta which binds to DNA mismatches thereby initiating DNA repair. It undergoes frequent somatic mutation in colorectal cancers (CRCs) with MMR deficiency. MSH3 mismatch repair protein regulates sensitivity to cytotoxic drugs and a histone deacetylase inhibitor in human colon carcinoma cells.

Aliases: MutS Homolog 3, FAP4

Molecular Weight: 127 kDa

Pathways: DNA Damage Repair, Production of Molecular Mediator of Immune Response