Recombinant SMAD1 antibody (pSer214)

Catalog No. ABIN7938496

This Rabbit Monoclonal antibody specifically detects SMAD1 in WB. It exhibits reactivity toward Human and Mouse.

Quick Overview for Recombinant SMAD1 antibody (pSer214) (ABIN7938496)

Target: SMAD1 (SMAD, Mothers Against DPP Homolog 1 (SMAD1))

Antibody Type: Recombinant Antibody

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Monoclonal

Conjugate: This SMAD1 antibody is un-conjugated

Application: Western Blotting (WB)

Clone: 3K8

Product Details anti-SMAD1 Antibody

Binding Specificity: pSer214

Purpose: SMAD1 phospho Ser214 (rAb), 100 μl (Clone 3K8)

Purification: Protein A Chromatography

Immunogen: This information is proprietary to Active Motif and/or its suppliers.

Isotype: IgG

Application Details

Application Notes: WB: 1:2000-1:168000 dilution

Restrictions: For Research Use only

Handling

Buffer: Purified IgG in PBS, pH 7.3, with 50 % glycerol and 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze/thaw cycles by aliquoting items into single-use fractions,Keep all reagents on ice when not in storage

Storage: -20 °C

Storage Comment: Some products may be shipped at room temperature. This will not affect their stability or performance. Avoid repeated freeze/thaw cycles by aliquoting items into single-use fractions for storage at -20°C for up to 2 years. Keep all reagents on ice when not in storage.

Expiry Date: 24 months

Target Details for SMAD1

Target: SMAD1 (SMAD, Mothers Against DPP Homolog 1 (SMAD1))

Alternative Name: SMAD1

Background: SMAD family member 1 (SMAD1) have been involved in metastatic progression of many cancer types. SMAD1) can be induced by many tumor-stimulating cytokines such as the bone morphogenetic protein 2 (BMP2) and TNFa and plays important roles in cell invasion and metastasis. BMP2 signaling is initiated by binding to its specific receptors, which leads to in the phosphorylation and nuclear translocation of Smad1. Translocated SMAD1) then modulates the expression of downstream osteogenic genes.

Molecular Weight: 52 kDa

Pathways: Stem Cell Maintenance, Regulation of Muscle Cell Differentiation, Skeletal Muscle Fiber Development