Recombinant SOX2 antibody

Catalog No. ABIN7938504

The Rabbit Monoclonal anti-SOX2 antibody (Clone 230225G1) (ABIN7938504) specifically detects SOX2 in IF. The antibody is reactive with Human samples.

Quick Overview for Recombinant SOX2 antibody (ABIN7938504)

Target: SOX2 (SRY (Sex Determining Region Y)-Box 2 (SOX2))

Antibody Type: Recombinant Antibody

Reactivity: Human

Host: Rabbit

Clonality: Monoclonal

Conjugate: This SOX2 antibody is un-conjugated

Application: Immunofluorescence (IF)

Clone: 230225G1

Product Details anti-SOX2 Antibody

Purpose: SOX2 antibody (rAb), 100 μg (Clone 230225G1)

Purification: Protein A Chromatography

Immunogen: This antibody was raised against the SOX2 fusion protein.

Isotype: IgG

Application Details

Application Notes: IF: 1:150-1:600 dilution

Restrictions: For Research Use only

Handling

Buffer: Purified IgG in PBS, pH 7.3, with 50 % glycerol and 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze/thaw cycles by aliquoting items into single-use fractions,Keep all reagents on ice when not in storage

Storage: -20 °C

Storage Comment: Some products may be shipped at room temperature. This will not affect their stability or performance. Avoid repeated freeze/thaw cycles by aliquoting items into single-use fractions for storage at -20°C for up to 2 years. Keep all reagents on ice when not in storage.

Expiry Date: 24 months

Target Details for SOX2

Target: SOX2 (SRY (Sex Determining Region Y)-Box 2 (SOX2))

Alternative Name: SOX2

Background:

Background_Plain: Sox2 (SRY related HMG BOX gene 2) is a DNA binding transcription factor and a member of the SOX family of proteins. SOX proteins have an HMG box that binds DNA. Sox2 forms a complex with Oct-4 and controls the expression of a number of genes involved in embryonic. Sox2 is critical for early embryogenesis and for embryonic stem cell pluripotency and thus can serve as a stem cell marker. Overexpression of Sox2 (along with Oct-4, KLF4 and c-Myc) can transform mouse fibroblasts into a state resembling embryonic stem cells (ES cells), referred to as Induced Pluripotency. Defects in Sox2 are the cause of microphthalmia syndromic type 3.

Aliases: ANOP3, MCOPS3

Molecular Weight: 34 kDa

Pathways: Dopaminergic Neurogenesis, Sensory Perception of Sound, Stem Cell Maintenance, Cell RedoxHomeostasis