Recombinant TARDBP antibody

Catalog No. ABIN7938518

The Rabbit Monoclonal anti-TARDBP antibody is suitable to detect TARDBP in samples from Human, Mouse and Rat. It has been validated for WB.

Quick Overview for Recombinant TARDBP antibody (ABIN7938518)

Target: TARDBP (TAR DNA Binding Protein (TARDBP))

Antibody Type: Recombinant Antibody

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Monoclonal

Conjugate: This TARDBP antibody is un-conjugated

Application: Western Blotting (WB)

Clone: 11N20

Product Details anti-TARDBP Antibody

Purpose: TARDBP antibody (rAb), 100 μl (Clone 11N20)

Purification: Protein A Chromatography

Immunogen: This information is proprietary to Active Motif and/or its suppliers.

Isotype: IgG

Application Details

Application Notes: WB: 1:5000-1:50000 dilution

Restrictions: For Research Use only

Handling

Buffer: Purified IgG in PBS, pH 7.3, with 50 % glycerol and 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze/thaw cycles by aliquoting items into single-use fractions,Keep all reagents on ice when not in storage

Storage: -20 °C

Storage Comment: Some products may be shipped at room temperature. This will not affect their stability or performance. Avoid repeated freeze/thaw cycles by aliquoting items into single-use fractions for storage at -20°C for up to 2 years. Keep all reagents on ice when not in storage.

Expiry Date: 24 months

Target Details for TARDBP

Target: TARDBP (TAR DNA Binding Protein (TARDBP))

Alternative Name: TARDBP

Background:

Background_Plain: The TARDBP gene encodes the TDP-43 protein, initially found to repress HIV-1 transcription by binding TAR DNA. TDP-43 has since been shown to bind RNA as well as DNA, and have multiple functions in transcriptional repression, translational regulation and pre-mRNA splicing. For instance, it is reported to regulate alternate splicing of the CTFR gene. In 2006 Neumann et al. found that hyperphosphorylated, ubiquitinated and/or cleaved forms of TDP-43, collectively known as pathological TDP-43, play a major role in the disease mechanisms of ubiquitin-positive, tau- and alpha-synuclein-negative frontotemporal dementia (FTLD-U) and in amyotrophic lateral sclerosis (ALS).

Aliases: TAR DNA-binding protein 43, ALS10, TDP-43

Molecular Weight: 43 kDa

Pathways: Positive Regulation of Peptide Hormone Secretion