Recombinant TARDBP antibody (C-Term)

Catalog No. ABIN7938519

The Rabbit Monoclonal anti-TARDBP antibody (Clone 5D17) (ABIN7938519) specifically detects TARDBP in WB and IHC. The antibody is reactive with Human, Mouse and Rat samples.

Quick Overview for Recombinant TARDBP antibody (C-Term) (ABIN7938519)

Target: TARDBP (TAR DNA Binding Protein (TARDBP))

Antibody Type: Recombinant Antibody

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Monoclonal

Conjugate: This TARDBP antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Clone: 5D17

Product Details anti-TARDBP Antibody

Binding Specificity: C-Term

Purpose: TARDBP (C-terminal) (rAb), 100 μg (Clone 5D17)

Purification: Protein A Chromatography

Immunogen: This information is proprietary to Active Motif and/or its suppliers.

Isotype: IgG

Application Details

Application Notes: WB: 1:5000-1:50000 dilution IHC: 1:1000-1:4000 dilution

Restrictions: For Research Use only

Handling

Buffer: Purified IgG in PBS, pH 7.3, with 50 % glycerol and 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze/thaw cycles by aliquoting items into single-use fractions,Keep all reagents on ice when not in storage

Storage: -20 °C

Storage Comment: Some products may be shipped at room temperature. This will not affect their stability or performance. Avoid repeated freeze/thaw cycles by aliquoting items into single-use fractions for storage at -20°C for up to 2 years. Keep all reagents on ice when not in storage.

Expiry Date: 24 months

Target Details for TARDBP

Target: TARDBP (TAR DNA Binding Protein (TARDBP))

Alternative Name: TARDBP

Background:

Background_Plain: TARDBP (TAR DNA-binding protein 43) also known as ALS10 and TDP-43. TARDBP is a RNA-binding protein that is involved in various steps of RNA biogenesis and processing. Preferentially binds, via its two RNA recognition motifs RRM1 and RRM2, to GU-repeats on RNA molecules predominantly localized within long introns and in the 3'UTR of mRNAs. In turn, regulates the splicing of many non-coding and protein-coding RNAs including proteins involved in neuronal survival, as well as mRNAs that encode proteins relevant for neurodegenerative diseases. In addition, TARDBP also has a variety of biological functions, such as plays a role in maintaining mitochondrial homeostasis by regulating the processing of mitochondrial transcripts, regulates also mRNA stability, participates also in the normal skeletal muscle formation and regeneration, negatively regulates the expression of CDK6 and regulates the expression of HDAC6, ATG7 and VCP in a PPIA/CYPA-dependent manner.

Aliases: TAR DNA-binding protein 43, ALS10, TDP-43

Molecular Weight: 43 kDa

Pathways: Positive Regulation of Peptide Hormone Secretion