Recombinant TARDBP antibody (pSer409, pSer410)

Catalog No. ABIN7938522

The Rabbit Monoclonal anti-TARDBP antibody (Clone 6M10) (ABIN7938522) specifically detects TARDBP in WB. The antibody is reactive with Human and Mouse samples.

Quick Overview for Recombinant TARDBP antibody (pSer409, pSer410) (ABIN7938522)

Target: TARDBP (TAR DNA Binding Protein (TARDBP))

Antibody Type: Recombinant Antibody

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Monoclonal

Conjugate: This TARDBP antibody is un-conjugated

Application: Western Blotting (WB)

Clone: 6M10

Product Details anti-TARDBP Antibody

Binding Specificity: pSer409, pSer410

Purpose: TDP43 phospho Ser409/410 antibody (rAb), 100 μg (Clone 6M10)

Purification: Protein A Chromatography

Immunogen: This information is proprietary to Active Motif and/or its suppliers.

Isotype: IgG

Application Details

Application Notes: WB: 1:5000-1:50000 dilution

Restrictions: For Research Use only

Handling

Buffer: Purified IgG in PBS, pH 7.3, with 50 % glycerol and 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze/thaw cycles by aliquoting items into single-use fractions,Keep all reagents on ice when not in storage

Storage: -20 °C

Storage Comment: Some products may be shipped at room temperature. This will not affect their stability or performance. Avoid repeated freeze/thaw cycles by aliquoting items into single-use fractions for storage at -20°C for up to 2 years. Keep all reagents on ice when not in storage.

Expiry Date: 24 months

Target Details for TARDBP

Target: TARDBP (TAR DNA Binding Protein (TARDBP))

Alternative Name: TDP43

Background: TDP-43) was first isolated as a transcriptional inactivator binding to the TAR DNA element of the HIV-1 virus. Neumann et al. (2006) found that a hyperphosphorylated, ubiquitinated, and cleaved form of TARDBP, known as pathologic TDP-43, is the major component of the tau-negative and ubiquitin-positive inclusions that characterize amyotrophic lateral sclerosis (ALS) and the most common pathological subtype of frontotemporal lobar degeneration (FTLD-U).

Molecular Weight: 43 kDa

NCBI Accession: NM_007375

Pathways: Positive Regulation of Peptide Hormone Secretion