OGFOD3 antibody (AA 67-311) (Biotin)

Catalog No. ABIN7964801

The Rabbit Polyclonal anti-OGFOD3 antibody is suitable to detect OGFOD3 in samples from Human, Mouse and Rat. It has been validated for WB, ELISA and IHC.

Quick Overview for OGFOD3 antibody (AA 67-311) (Biotin) (ABIN7964801)

Target: OGFOD3 (2-Oxoglutarate and Iron-Dependent Oxygenase Domain Containing 3 (OGFOD3))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This OGFOD3 antibody is conjugated to Biotin

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC)

Product Details anti-OGFOD3 Antibody (Biotin)

Binding Specificity: AA 67-311

Purpose: Anti-OGFOD3 Antibody Biotin Conjugated

Predicted Reactivity: Human OGFOD3 shares 92.2%,90.6% amino acid (aa) sequence identity with mouse,rat OGFOD3,respectively.

Purification: Immunogen affinity purified.

Immunogen: E.coli-derived human OGFOD3 recombinant protein (Position: D67-H311). Human OGFOD3 shares 92.2% and 90.6% amino acid (aa) sequence identity with mouse and rat OGFOD3, respectively.

Isotype: IgG

Application Details

Application Notes: Western blot, Optimal dilutions should be determined by end users. Immunohistochemistry (Paraffin-embedded Section), Optimal dilutions should be determined by end users. ELISA, Optimal dilutions should be determined by end users.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Each vial contains 50 % glycerol, 0.9 % NaCl, 0.2 % Na2HPO4, 0.02 % Sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: At -20°C for one year from date of receipt. Avoid repeated freezing and thawing.

Expiry Date: 12 months

Target Details for OGFOD3

Target: OGFOD3 (2-Oxoglutarate and Iron-Dependent Oxygenase Domain Containing 3 (OGFOD3))

Alternative Name: OGFOD3

Background:

Background: OGFOD3 (2-oxoglutarate and iron-dependent oxygenase domain-containing protein 3) is a protein involved in the hydroxylation of transfer RNA (tRNA), specifically targeting tRNA-hypoxanthine modification. This process is crucial for maintaining accurate translation and protein synthesis in cells. OGFOD3 belongs to the family of 2-oxoglutarate (2OG)-dependent oxygenases, which require iron and 2OG as cofactors to catalyze various oxidative reactions. Its role highlights the importance of tRNA modifications in cellular physiology, potentially influencing gene expression and protein function regulation.

Gene Full Name: 2-oxoglutarate and iron dependent oxygenase domain containing 3

Gene ID: 79701

UniProt: Q6PK18