MTRR antibody (AA 7-698) (Biotin)

Catalog No. ABIN7965110

The Rabbit Polyclonal anti-MTRR antibody is suitable to detect MTRR in samples from Human, Mouse and Rat. It has been validated for ELISA, WB and IHC.

Quick Overview for MTRR antibody (AA 7-698) (Biotin) (ABIN7965110)

Target: MTRR (5-Methyltetrahydrofolate-Homocysteine Methyltransferase Reductase (MTRR))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This MTRR antibody is conjugated to Biotin

Application: ELISA, Western Blotting (WB), Immunohistochemistry (IHC)

Product Details anti-MTRR Antibody (Biotin)

Binding Specificity: AA 7-698

Purpose: Anti-MTRR Antibody Biotin Conjugated

Cross-Reactivity (Details): No cross-reactivity with other proteins

Predicted Reactivity: Human MTRRshares 78.3%,79% amino acid (aa) sequence identity with mouse,rat MTRR,respectively.

Purification: Immunogen affinity purified.

Immunogen: E.coli-derived human MTRR recombinant protein (Position: L7-S698). Human MTRRshares 78.3% and 79% amino acid (aa) sequence identity with mouse and rat MTRR, respectively.

Isotype: IgG

Application Details

Application Notes: Western blot, Optimal dilutions should be determined by end users. Immunohistochemistry (Paraffin-embedded Section), Optimal dilutions should be determined by end users. ELISA, Optimal dilutions should be determined by end users.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Each vial contains 50 % glycerol, 0.9 % NaCl, 0.2 % Na2HPO4, 0.02 % Sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: At -20°C for one year from date of receipt. Avoid repeated freezing and thawing.

Expiry Date: 12 months

Target Details for MTRR

Target: MTRR (5-Methyltetrahydrofolate-Homocysteine Methyltransferase Reductase (MTRR))

Alternative Name: MTRR

Background:

Background: This gene encodes a member of the ferredoxin-NADP(+) reductase (FNR) family of electron transferases. This protein functions in the synthesis of methionine by regenerating methionine synthase to a functional state. Because methionine synthesis requires methyl-group transfer by a folate donor, activity of the encoded enzyme is important for folate metabolism and cellular methylation. Mutations in this gene can cause homocystinuria-megaloblastic anemia, cbl E type. Alternative splicing of this gene results in multiple transcript variants.

Gene Full Name: 5-methyltetrahydrofolate-homocysteine methyltransferase reductase

Gene ID: 4552

UniProt: Q9UBK8

Pathways: Methionine Biosynthetic Process