ABI1 antibody (C-Term) (Fluoro647)

Catalog No. ABIN7965350

The Rabbit Polyclonal anti-ABI1 antibody is suitable to detect ABI1 in samples from Human, Rat and Mouse. It has been validated for FACS.

Quick Overview for ABI1 antibody (C-Term) (Fluoro647) (ABIN7965350)

Target: ABI1 (Abl-Interactor 1 (ABI1))

Reactivity: Human, Rat, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This ABI1 antibody is conjugated to Fluoro647

Application: Flow Cytometry (FACS)

Product Details anti-ABI1 Antibody (Fluoro647)

Binding Specificity: C-Term

Purpose: Anti-SSH3BP1/ABI1 Antibody Fluoro647 Conjugated

Specificity: No cross reactivity with other proteins.

Cross-Reactivity (Details): No cross-reactivity with other proteins.

Predicted Reactivity: different from the related rat,mouse sequences by one amino acid.

Purification: Immunogen affinity purified.

Immunogen: A synthetic peptide corresponding to a sequence at the C-terminus of human ABI1, different from the related rat and mouse sequences by one amino acid.

Isotype: IgG

Application Details

Application Notes: Flow Cytometry, Optimal dilutions should be determined by end users.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Each vial contains 50 % glycerol, 0.9 % NaCl, 0.2 % Na2HPO4, 0.02 % Sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: At -20°C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Expiry Date: 12 months

Target Details for ABI1

Target: ABI1 (Abl-Interactor 1 (ABI1))

Alternative Name: ABI1

Background:

Background: ABI1 is a human homolog of mouse Abl-interactor-1 (Abi1), mapped on 10p11.2. ABI1 participates in the transduction of signals from Ras to Rac by regulating Rac-specific guanine nucleotide exchange factor (GEF) activities. ABI1 dramatically promoted ABL1-mediated tyrosine phosphorylation of MENA, but not of other substrates. Abi-1 regulates c-Abl-mediated phosphorylation of Mena by interacting with both proteins. ABI1 plays a role in the leukemogenesis by translocating to MLL.

Gene Full Name: abl interactor 1

Sequence Similarities: Contains 12 fibronectin type-I domains.

Gene ID: 10006

UniProt: Q8IZP0

Pathways: RTK Signaling, Response to Water Deprivation, ER-Nucleus Signaling