Amphiregulin antibody (AA 101-180) (Biotin)

Catalog No. ABIN7968146

The Rabbit Polyclonal anti-Amphiregulin antibody is suitable to detect Amphiregulin in samples from Human. It has been validated for WB, IHC and ELISA.

Quick Overview for Amphiregulin antibody (AA 101-180) (Biotin) (ABIN7968146)

Target: Amphiregulin (AREG)

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Amphiregulin antibody is conjugated to Biotin

Application: Western Blotting (WB), Immunohistochemistry (IHC), ELISA

Product Details anti-Amphiregulin Antibody (Biotin)

Binding Specificity: AA 101-180

Purpose: Anti-Amphiregulin/AREG Antibody Biotin Conjugated

Cross-Reactivity (Details): No cross-reactivity with other proteins.

Purification: Immunogen affinity purified.

Immunogen: E.coli-derived human Amphiregulin/AREG recombinant protein (Position: S101-R180).

Isotype: IgG

Application Details

Application Notes: Western blot, Optimal dilutions should be determined by end users. Immunohistochemistry (Paraffin-embedded Section), Optimal dilutions should be determined by end users. ELISA, Optimal dilutions should be determined by end users.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Each vial contains 50 % glycerol, 0.9 % NaCl, 0.2 % Na2HPO4, 0.02 % Sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: At -20°C for one year from date of receipt. Avoid repeated freezing and thawing.

Expiry Date: 12 months

Target Details for Amphiregulin

Target: Amphiregulin (AREG)

Alternative Name: AREG

Background:

Background: Amphiregulin, also known as AREG, is a protein that in humans is encoded by the AREG gene. The protein encoded by this gene is a member of the epidermal growth factor (EGF) family. It is an autocrine growth factor as well as a mitogen for astrocytes, Schwann cells, fibroblasts. It is related to epidermal growth factor (EGF) and transforming growth factor alpha (TGF-alpha). This protein interacts with the Epidermal growth factor receptor (EGFR) to promote the growth of normal epithelial cells. It is mapped to 9q32. It has been shown to play a role in immunity, inflammation, tissue repair, and lung and mammary gland development. Homozygous knockout mice for this gene exhibit impaired immune system regulation in the skin and gene expression changes characteristic of chronic liver damage.

Gene Full Name: amphiregulin

Gene ID: 374

UniProt: P15514

Pathways: RTK Signaling, EGFR Signaling Pathway