Amphiregulin antibody (AA 101-180)

Catalog No. ABIN7968156

The Rabbit Polyclonal anti-Amphiregulin antibody (ABIN7968156) specifically detects Amphiregulin in WB, ELISA and FACS. The antibody is reactive with Human samples.

Quick Overview for Amphiregulin antibody (AA 101-180) (ABIN7968156)

Target: Amphiregulin (AREG)

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Amphiregulin antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Flow Cytometry (FACS)

Grade: Carrier-free

Product Details anti-Amphiregulin Antibody

Binding Specificity: AA 101-180

Purpose: Anti-Amphiregulin/AREG Antibody

Cross-Reactivity (Details): No cross-reactivity with other proteins.

Characteristics: Anti-Amphiregulin/AREG Antibody. Tested in ELISA, Flow Cytometry, WB applications. This antibody reacts with Human.

Purification: Immunogen affinity purified.

Immunogen: E.coli-derived human Amphiregulin/AREG recombinant protein (Position: S101-R180).

Isotype: IgG

Application Details

Application Notes: Western blot, 0.25-0.5 μg/mL/mL, Human Flow Cytometry (Fixed), 1-3 μg/1x10⁶ cells, Human ELISA, 0.1-0.5 μg/mL/mL, Human

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

Concentration: 500 μg/mL

Buffer: Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.

Storage: 4 °C,-20 °C

Storage Comment: At -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freezing and thawing.

Expiry Date: 12 months

Target Details for Amphiregulin

Target: Amphiregulin (AREG)

Alternative Name: AREG

Background:

Background: Amphiregulin, also known as AREG, is a protein that in humans is encoded by the AREG gene. The protein encoded by this gene is a member of the epidermal growth factor (EGF) family. It is an autocrine growth factor as well as a mitogen for astrocytes, Schwann cells, fibroblasts. It is related to epidermal growth factor (EGF) and transforming growth factor alpha (TGF-alpha). This protein interacts with the Epidermal growth factor receptor (EGFR) to promote the growth of normal epithelial cells. It is mapped to 9q32. It has been shown to play a role in immunity, inflammation, tissue repair, and lung and mammary gland development. Homozygous knockout mice for this gene exhibit impaired immune system regulation in the skin and gene expression changes characteristic of chronic liver damage.

Gene Full Name: amphiregulin

Molecular Weight: 45 kDa

Gene ID: 374

UniProt: P15514

Pathways: RTK Signaling, EGFR Signaling Pathway