APCS antibody (AA 21-224) (APC)

Catalog No. ABIN7968329

The Rabbit Polyclonal anti-APCS antibody is suitable to detect APCS in samples from Mouse and Rat. It has been validated for FACS.

Quick Overview for APCS antibody (AA 21-224) (APC) (ABIN7968329)

Target: APCS (Amyloid P Component, Serum (APCS))

Reactivity: Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This APCS antibody is conjugated to APC

Application: Flow Cytometry (FACS)

Product Details anti-APCS Antibody (APC)

Binding Specificity: AA 21-224

Purpose: Anti-Serum Amyloid P/APCS Antibody APC Conjugated

Specificity: No cross reactivity with other proteins.

Cross-Reactivity (Details): No cross-reactivity with other proteins

Predicted Reactivity: Mouse Serum Amyloid P shares 70%,80% amino acid (aa) sequences identity with human,rat Serum Amyloid P,respectively.

Purification: Immunogen affinity purified.

Immunogen: E.coli-derived mouse Serum Amyloid P recombinant protein (Position: Q21-D224). Mouse Serum Amyloid P shares 70% and 80% amino acid (aa) sequences identity with human and rat Serum Amyloid P, respectively.

Isotype: IgG

Application Details

Application Notes: Flow Cytometry, Optimal dilutions should be determined by end users.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Each vial contains 50 % glycerol, 0.9 % NaCl, 0.2 % Na2HPO4, 0.02 % Sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: At -20°C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Expiry Date: 12 months

Target Details for APCS

Target: APCS (Amyloid P Component, Serum (APCS))

Alternative Name: APCS

Background:

Background: Amyloid P component, serum (SAP), also known as PTX2 or APCS, is the identical serum form of amyloid P component (AP), a 25 kDa pentameric protein first identified as the pentagonal constituent of in vivo pathological deposits called amyloid. It belongs to the pentraxins family, characterised by calcium dependent ligand binding and distinctive flattened beta-jellyroll structure similar to that of the legume lectins. This gene is mapped to 1q23.2. The binding of the encoded protein to proteins in the pathological amyloid cross-beta fold suggests its possible role as a chaperone. This protein is also thought to control the degradation of chromatin. It has been demonstrated that this protein binds to apoptotic cells at an early stage, which raises the possibility that it is involved in dealing with apoptotic cells in vivo.

Gene Full Name: amyloid P component, serum

Sequence Similarities: Belongs to the pentaxin family.

Gene ID: 20219

UniProt: P12246